... that is the driving force behind vascular regression (Rao et al., 2007). In turn, this implied that MYC, a key regulator of cell cycle entry and a Wnt/β-catenin pathway target gene (He et al., 1998), might also be required for hyaloid regression. To test this possibility, we performed a conditional deletion...

... cell death. Here we show that during developmentally scheduled vascular regression,resident macrophages are an obligatory participant in a signaling switch that favors death over survival. This switch occurs when the signaling ligand angiopoietin 2 has the dual effect of suppressing survival signaling...

... 1999 19 04 1999 © 1999 by Company of Biologists 1999 Apoptosis Macrophage Vascular regression Tissue remodeling Tissue regression The ability of an organism to maintain homeostasis is dependent upon a balance between cell proliferation, cell death and differentiation...

... Southwestern Medical Center, 5323 Harry Hines Blvd, NB11.200, Dallas, TX 75235-8573, USA § Author for correspondence (e-mail: [email protected]) 11 01 1999 03 03 1999 © 1999 by Company of Biologists 1999 Apoptosis Vascular regression Tissue remodelling Tissue regression...

... 07 1997 © 1997 by Company of Biologists 1997 apoptosis macrophage vascular regression tissue remodeling tissue regression rat eye Despite decades of interest in the function of macrophages, the in vivo significance of their ability to kill non-immune target cells...

... apoptosis vascular regression macrophage tissue remodelling tissue regression rat capillary regression Programmed capillary regression is a frequent occurrence in development. Despite the prevalence of this event, and the potential therapeutic value of an understanding of its mechanism...

... the interdigital necrotic process responsible for the freeing of the digits is followed by regression of the blood vessels. In the webbed foot of the duck, the interdigital necrotic processes are not followed by vascular regression. Transmission electron microscopic studies show that both in the chick...