...Saptarshi Biswas; Sanjid Shahriar; Nicholas P. Giangreco; Panos Arvanitis; Markus Winkler; Nicholas P. Tatonetti; William J. Brunken; Tyler Cutforth; Dritan Agalliu ABSTRACT Neurovascular unit and barrier maturation rely on vascular basement membrane (vBM) composition. Laminins, a major vBM...

... doppel interacts with endothelial receptor tyrosine kinases to activate intracellular signaling pathways and promote blood vessel morphogenesis in the developing central nervous system. Vascular basement membrane Microenvironment Neurovascular unit Extracellular matrix Astrocyte Barriergenesis...

... vascular basement membrane, which in turn results in enhanced dorsal aorta vessel elasticity and failure to restrict aortic diameter. Our results provide direct in vivo evidence for a functional role for mural cells in patterning and stabilization of the early vasculature through production and maintenance...