...Zhen-Yu Wang; Armaan Mehra; Qian-Chen Wang; Savita Gupta; Agatha Ribeiro da Silva; Thomas Juan; Stefan Günther; Mario Looso; Jan Detleffsen; Didier Y. R. Stainier; Rubén Marín-Juez ABSTRACT VEGFA administration has been explored as a pro-angiogenic therapy for cardiovascular diseases including...

... , R. , Ferrara , N. , Johnson , R. S. , Schipani , E. and Olsen , B. R. ( 2004 ). VEGFA is necessary for chondrocyte survival during bone development . Development   131 , 2161 - 2171 . 10.1242/dev.01053 Zhang , Z. , Ramirez , N. E. , Yankeelov , T. E. , Li...

...Masahiro Shin; Timothy J. Beane; Aurelie Quillien; Ira Male; Lihua J. Zhu; Nathan D. Lawson Vascular endothelial growth factor a (Vegfa) is essential for blood vessel formation and can induce activation of numerous signaling effectors in endothelial cells. However, it is unclear how and where...

... neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells. Conditional deletion of the Crim1 gene in vascular endothelial cells (VECs) causes delayed vessel expansion and reduced vessel density. Based on known Vegfa binding by Crim1 and Crim1 expression...

.... VEGF-A Vegfa Axon guidance Neurogenesis Neuron Neuronal migration and survival During embryonic development of vertebrates, a multitude of growth factors and guidance cues cooperate to regulate the formation of the vascular and neuronal networks that are essential for tissue...

... but deficiencies of Vegfa, Mmp13, RANKL and osteopontin expression in the non-resorbed hypertrophic cartilage, indicating that Sox9 misexpression in hypertrophic chondrocytes inhibits their terminal differentiation. Searching for the molecular mechanism of SOX9-induced inhibition of cartilage vascularization, we...

...Elazar Zelzer; Roni Mamluk; Napoleone Ferrara; Randall S. Johnson; Ernestina Schipani; Bjorn R. Olsen To directly examine the role of vascular endothelial growth factor (VEGFA)in cartilage development, we conditionally knocked out Vegfa in chondrocytes, using the Col2a1 promoter to drive expression...

... endothelial growth factor A (VEGFA) expression was temporally and spatially correlated with PNVP formation, suggesting it is a component of the neural tube signal. A collagen explant model was developed in which presomitic mesoderm explants formed a vascular plexus in the presence of added VEGFA. Co-cultures...

...Annette Damert; Lucile Miquerol; Marina Gertsenstein; Werner Risau; Andras Nagy Vascular endothelial growth factor A (VEGFA) plays a pivotal role in the first steps of endothelial and haematopoietic development in the yolk sac, as well as in the establishment of the cardiovascular system...