...Lynda Erskine; Urielle François; Laura Denti; Andy Joyce; Miguel Tillo; Freyja Bruce; Neil Vargesson; Christiana Ruhrberg Visual information is relayed from the eye to the brain via retinal ganglion cell (RGC) axons. Mice lacking NRP1 or NRP1-binding VEGF-A isoforms have defective RGC axon...

... the frequency of transient contacts that occur before vessels form stable connections and target site selectivity. Angiogenesis Endothelial cells Anastomosis VEGF-A VEGFR1 Flt1 isoforms Blood vessel formation is an essential, conserved process in vertebrates that provides oxygen and nutrients...

...Francesca Mackenzie; Christiana Ruhrberg Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of neuronal functions, both in vitro and in vivo, including neurogenesis...