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Keywords: VEGF
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Journal Articles
Journal: Development
Development (2021) 148 (10): dev180760.
Published: 27 May 2021
... and arm regeneration of the brittle Amphiura filiformis identify a conserved role in the formation of the skeleton in both processes. Echinoderm Biomineralization Regulatory networks Signalling Vegf A tempting theory for the evolutionary origins of tissue regeneration suggests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev173674.
Published: 4 November 2019
... negative version of Vegfaa (dnVegfaa) in β-cells led to vascular and endocrine cell disruption with a minor impairment in β-cell function. In contrast, expression of a soluble isoform of Vegf receptor 1 (sFlt1) in β-cells blocked the formation of the pancreatic vasculature and drastically stunted glucose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev151019.
Published: 20 July 2018
...Sinem Karaman; Veli-Matti Leppänen; Kari Alitalo ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2249–2260.
Published: 1 July 2016
... - 162 . 10.1016/S0070-2153(09)89006-6 Baum , O. , Suter , F. , Gerber , B. , Tschanz , S. A. , Buergy , R. , Blank , F. , Hlushchuk , R. and Djonov , V. ( 2010 ). VEGF-A promotes intussusceptive angiogenesis in the developing chicken chorioallantoic membrane...
Journal Articles
Journal: Development
Development (2016) 143 (3): 373–386.
Published: 1 February 2016
.... Endocardium Cardiac development Hemodynamics Bmp Krüppel-like factor 2 Vegf Mechanotransduction Zebrafish Mouse The developmental origins of the endocardium have been intensely investigated, although the molecular control and the timing of endocardial cell fate specification are currently...
Journal Articles
Journal: Development
Development (2016) 143 (2): 348–355.
Published: 15 January 2016
... the discrepancy between the in vitro and in vivo hypertrophic chondrocyte phenotypes revealed normal chondrocyte differentiation in c-Raf f/f ;ColII-Cre + mice and lack of compensatory increase in the expression of A-Raf and B-Raf. However, VEGF (Vegfa) immunoreactivity in the hypertrophic chondrocytes of c-Raf f...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 147–159.
Published: 1 January 2016
... cells to enable intracerebral vascularization and proper expression of molecular markers associated with BBB formation. Additional studies with cultured endothelial cells suggest that, in other contexts, Reck impacts vascular biology via the vascular endothelial growth factor (VEGF) cascade. Together...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (13): 2364–2374.
Published: 1 July 2015
... in ECs in response to stimulation by vascular endothelial growth factor (VEGF). We found that CCN1 activity is integrated with VEGF receptor 2 (VEGF-R2) activation and downstream signaling pathways required for tubular network formation. CCN1-integrin binding increased the expression of and association...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1480–1491.
Published: 1 April 2014
... of organs, but the mechanisms leading to this arrangement are incompletely understood. Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. In mature islets, nerves are closely associated with capillaries...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 556–562.
Published: 1 February 2014
...Alessandro Fantin; Birger Herzog; Marwa Mahmoud; Maiko Yamaji; Alice Plein; Laura Denti; Christiana Ruhrberg; Ian Zachary Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development. Biochemical evidence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4881–4889.
Published: 15 December 2013
... no competing financial interests. 25 2 2013 12 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Wnt5 Sea urchin VEGF Ectoderm Specification In an embryo, tissue boundaries form when cells of two different gene regulatory states are juxtaposed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4214–4225.
Published: 15 October 2013
...Ashrifia Adomako-Ankomah; Charles A. Ettensohn Growth factor signaling pathways provide essential cues to mesoderm cells during gastrulation in many metazoans. Recent studies have implicated the VEGF and FGF pathways in providing guidance and differentiation cues to primary mesenchyme cells (PMCs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2632–2642.
Published: 15 June 2013
... endogenous VEGFA signalling. This response depends on expression of the VEGF receptor Flk1, driven by Fli1 and Gata2. Scl activation requires synergy between this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/Etsrp/ER71, which also drives expression of the Scl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4356–4365.
Published: 1 December 2012
... for miRNAs as regulators of cross-tissue signaling. The identification of miR-1/206-mediated regulation of Vegf might be significant beyond developmental angiogenesis. A pivotal step in solid tumor progression and metastasis is the invasion or co-option of capillaries, which provide growing tumors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5357–5368.
Published: 15 December 2011
... Competing interests statements The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4743–4752.
Published: 1 November 2011
..., VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4185–4191.
Published: 1 October 2011
... growth factor (VEGF) and class 3 semaphorin families through its extracellular domain, it also has a highly conserved cytoplasmic domain, which terminates in a SEA motif that binds the PDZ protein synectin/GIPC1/NIP. Previous studies in zebrafish embryos and tissue culture models raised the possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3723–3733.
Published: 1 September 2011
... VEGF164 promotes the survival of migrating GnRH neurons by co-activating the ERK and AKT signalling pathways through NRP1. We also demonstrate that survival signalling relies on neuronal, but not endothelial, NRP1 expression and that it occurs independently of KDR, the main VEGF receptor in blood vessels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2111–2120.
Published: 15 May 2011
... factor (VegfA). Here we present Flt1 (Vegf receptor 1) loss- and gain-of-function data in zebrafish showing that Flt1 regulates tip cell formation and arterial branching morphogenesis. Zebrafish embryos expressed soluble Flt1 (sFlt1) and membrane-bound Flt1 (mFlt1). In Tg(flt1 BAC :yfp) × Tg(kdrl:ras...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1409–1419.
Published: 1 April 2011
... and multiple Slit/Robo signaling components are required for heart tube formation in zebrafish and that this network modulates the previously unappreciated function of Vegf signaling in this process. These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide...
Includes: Multimedia, Supplementary data