... endothelial growth factor (Vegf), Notch and cxcr4a signalling. Subsequently, veins produced veins in more proximal fin regions, transforming pre-existing artery-vein loops into a three-vessel pattern consisting of an artery and two veins. A distinct set of vascular plexuses formed at the base of the fin...

... analyses of FGF signalling perturbation during embryonic development and arm regeneration of the brittle Amphiura filiformis identify a conserved role in the formation of the skeleton in both processes. Echinoderm Biomineralization Regulatory networks Signalling Vegf A tempting theory...

... negative version of Vegfaa (dnVegfaa) in β-cells led to vascular and endocrine cell disruption with a minor impairment in β-cell function. In contrast, expression of a soluble isoform of Vegf receptor 1 (sFlt1) in β-cells blocked the formation of the pancreatic vasculature and drastically stunted glucose...

...Sinem Karaman; Veli-Matti Leppänen; Kari Alitalo ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind...

... the formation of biological tubes . Curr. Top. Dev. Biol.   89 , 137 - 162 . 10.1016/S0070-2153(09)89006-6 Baum , O. , Suter , F. , Gerber , B. , Tschanz , S. A. , Buergy , R. , Blank , F. , Hlushchuk , R. and Djonov , V. ( 2010 ). VEGF-A promotes intussusceptive...

... migration requires Tal1, which plays dual roles in the establishment of intercellular junctions and the suppression of myocardial cell fates. VEGF signalling is required within ECs for midline migration; whereas Slit2/Robo1 signals positively regulate this process, Slit2 exerts negative regulation on Vegfr2...

... the discrepancy between the in vitro and in vivo hypertrophic chondrocyte phenotypes revealed normal chondrocyte differentiation in c-Raf f/f ;ColII-Cre + mice and lack of compensatory increase in the expression of A-Raf and B-Raf. However, VEGF (Vegfa) immunoreactivity in the hypertrophic chondrocytes of c-Raf f...

... cells to enable intracerebral vascularization and proper expression of molecular markers associated with BBB formation. Additional studies with cultured endothelial cells suggest that, in other contexts, Reck impacts vascular biology via the vascular endothelial growth factor (VEGF) cascade. Together...

... in ECs in response to stimulation by vascular endothelial growth factor (VEGF). We found that CCN1 activity is integrated with VEGF receptor 2 (VEGF-R2) activation and downstream signaling pathways required for tubular network formation. CCN1-integrin binding increased the expression of and association...

... of organs, but the mechanisms leading to this arrangement are incompletely understood. Here, we show that vascular endothelial growth factor (VEGF) signaling profoundly affects both vascularization and innervation of the pancreatic islet. In mature islets, nerves are closely associated with capillaries...

...Alessandro Fantin; Birger Herzog; Marwa Mahmoud; Maiko Yamaji; Alice Plein; Laura Denti; Christiana Ruhrberg; Ian Zachary Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development. Biochemical evidence...

... no competing financial interests. 25 2 2013 12 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Wnt5 Sea urchin VEGF Ectoderm Specification In an embryo, tissue boundaries form when cells of two different gene regulatory states are juxtaposed...

...Ashrifia Adomako-Ankomah; Charles A. Ettensohn Growth factor signaling pathways provide essential cues to mesoderm cells during gastrulation in many metazoans. Recent studies have implicated the VEGF and FGF pathways in providing guidance and differentiation cues to primary mesenchyme cells (PMCs...

... endogenous VEGFA signalling. This response depends on expression of the VEGF receptor Flk1, driven by Fli1 and Gata2. Scl activation requires synergy between this VEGFA-controlled pathway and a VEGFA-independent pathway controlled by Fli1, Gata2 and Etv2/Etsrp/ER71, which also drives expression of the Scl...

... the manuscript with feedback from Y.M., Y.S. and A.J.G. Competing interests statement The authors declare no competing financial interests. 24 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Angiogenesis MicroRNA miR-1 miR-206 VEGF Secreted signaling...

... The authors declare no competing financial interests. 5 10 2011 © 2011. Cardiogenesis Flk1 (Kdr) Hemangioblasts Hematopoiesis VEGF Vasculogenesis Mouse Mesodermal cells give rise to blood, blood vessel, kidney, cardiac and skeletal muscle. These tissues...

..., VEGF-induced hypervascularization decreases pancreas size. The growth phenotype results from vascular restriction of pancreatic tip cell formation, lateral branching and differentiation of the pancreatic epithelium into endocrine and acinar cells. The effects are seen both in vivo and ex vivo...

... growth factor (VEGF) and class 3 semaphorin families through its extracellular domain, it also has a highly conserved cytoplasmic domain, which terminates in a SEA motif that binds the PDZ protein synectin/GIPC1/NIP. Previous studies in zebrafish embryos and tissue culture models raised the possibility...

... VEGF164 promotes the survival of migrating GnRH neurons by co-activating the ERK and AKT signalling pathways through NRP1. We also demonstrate that survival signalling relies on neuronal, but not endothelial, NRP1 expression and that it occurs independently of KDR, the main VEGF receptor in blood vessels...

... factor (VegfA). Here we present Flt1 (Vegf receptor 1) loss- and gain-of-function data in zebrafish showing that Flt1 regulates tip cell formation and arterial branching morphogenesis. Zebrafish embryos expressed soluble Flt1 (sFlt1) and membrane-bound Flt1 (mFlt1). In Tg(flt1 BAC :yfp) × Tg(kdrl:ras...