...-cadherin. Boxed areas indicate the regions shown at higher magnification below. Scale bars: 5 μm. (D) Immunofluorescence analysis of control, ccm1 and heg1 morphants using anti-VE-cadherin and anti-Rasip1 antibodies at 48 hpf. Scale bars: 2 µm. White arrowheads indicate colocalization of VE-cadherin...

..., GATA2 is required for VEC maintenance and morphogenesis. GATA2 is also necessary for the expression of the cell junction molecules VE-cadherin and claudin 5 in lymphatic vessels. We identified miR-126 as a target of GATA2, and miR-126 −/− embryos recapitulate the phenotypes of mice lacking GATA2...

..., while allowing cell motility. We have compared the contribution of two endothelial cell-specific adhesion proteins, VE-cadherin (VE-cad/Cdh5) and Esama (endothelial cell-selective adhesion molecule a), during angiogenic sprouting and blood vessel fusion (anastomosis) in the zebrafish embryo by genetic...

... 2015 Summary: Cdc42 and its effectors Pak2/4 and N-WASP are required for organisation of the actin cytoskeleton during blood vessel development, both in filopodia and nascent cell-cell junctions. Cdc42 Vasculogenesis Blood vessel development F-actin VE-cadherin Filopodia Blood...

.... 30 8 2013 12 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 VE-Cadherin Hemogenic endothelium Mesoangioblasts Muscle Mouse The vascular and the hematopoietic systems are deeply entwined throughout embryonic development. The first endothelial cells (ECs...

... cells of the ISVs for in vivo lumen formation. Our analyses suggest that Moesin1 contributes to the maintenance of apical/basal cell polarity of the ISVs as defined by adherens junctions. Knockdown of the adherens junction protein Ve-cadherin disrupts formation of the apical membrane and lumen in a cell...

... through direct protein-protein interactions. Fig. 7. KLF2 is necessary and sufficient for expression of other vascular marker genes. In situ hybridization analysis of X-msr and VE-cadherin expression in injected Xenopus embryos (stage 34, lateral view). ( A-D ) Klf2 MO blocks expression...

... locations are marked by co-expression of the endothelial-specific marker VE-cadherin and the pan-leukocyte antigen CD45. Phenotypic characterisation using CD31, TIE2,FLK1, Ac-LDL receptors, and CD34 markers demonstrated significant similarities between this VE-cadherin + CD45 + `double-positive'population...

... order for blood cell differentiation: ES cell (E-cadherin + Flk1 ™ PDGFRα ™ ), proximal lateral mesoderm (E-cadherin ™ Flk1 + VEcadherin ™ ), progenitor with hemoangiogenic potential (Flk1 + VE-cadherin + CD45 ™ ), hemopoietic p rogenitor (CD45 + c-Kit + ) and mature blood cells (c-Kit ™ CD45...