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Keywords: Ureter
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Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
... transcription factors in the regulation of cell cycle progression. Tbx2/3cDKO ureters displayed an expansion of expression of genes encoding ECM proteins, particularly collagens and fibulins, into the inner SMC layer of the ureteric wall, and ectopic expression of TBX2 was sufficient to repress expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1893–1908.
Published: 15 May 2015
... ureteral muscle and bladder muscle intersect to form the anti-reflux valve ( Carpenter et al., 2012 ; Viana et al., 2007 ) ( Fig. 6 K,L). Differentiation of smooth muscle cells from the bladder mesenchyme begins at E13.5 in the outer peripheral zone of the primitive bladder and progresses inwards...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3099–3108.
Published: 01 September 2012
... of Ctnnb1 in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional obstruction of the ureter. Histological analysis revealed that the layer of undifferentiated mesenchymal cells directly adjacent to the ureteric epithelium did not undergo characteristic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3099–3106.
Published: 15 September 2010
... fails to initiate branching despite tip-specific expression of Ret and Wnt11 . The stalk-specific marker Wnt9b and the β-catenin downstream target Axin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...
Journal Articles
Journal: Development
Development (2010) 137 (5): 755–765.
Published: 01 March 2010
... epithelial tube ( Brenner-Anantharam et al., 2007 ). The ureteral mesenchymal cells are constantly expanded to provide a cellular resource for continuous ureter elongation. Interaction of these mesenchyme cells with urothelium is required for proper morphogenesis of the ureter. In response to signals from...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3301–3310.
Published: 01 October 2008
... urethra, and is central to the functions of these organs. As in other viscera, ureteric SM develops from local mesenchyme ( Yu et al.,2002 ) and hence the mouse ureter represents an appropriate paradigm to elucidate mechanisms controlling visceral SMC differentiation. Based on the above observations...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3763–3769.
Published: 15 October 2007
...-gestation when the ureters move from their primary insertion site in the Wolffian ducts to the trigone, a muscular structure comprising the bladder floor just above the urethra. Precise connections between the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however...
Journal Articles
Journal: Development
Development (2007) 134 (9): 1799–1807.
Published: 01 May 2007
... +/+ mice( Table 2 ). The proliferative index of Dlgh1 -/- mice at E12.5, when prominent elongation of the ureter occurs in normal mice, was significantly lower than that of Dlgh1 +/+ mice. This finding suggests that decreased proliferation in the ureteric epithelium causes the short ureter of Dlgh1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (22): 5301–5312.
Published: 15 November 2002
..., ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter— the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic...