... understood. Genetic lineage tracing revealed that in the developing ureter of the mouse, LP fibrocytes arise together with smooth muscle cells (SMCs) of the TM and fibrocytes of the outer tunica adventitia (TA) from a common mesenchymal progenitor pool that surrounds the epithelium of the distal ureteric bud...

...Anna-Carina Weiss; Eva Blank; Tobias Bohnenpoll; Marc-Jens Kleppa; Reginaldo Rivera-Reyes; Makoto Mark Taketo; Mark-Oliver Trowe; Andreas Kispert ABSTRACT The murine kidney and ureter develop in a regionalized fashion from the ureteric bud and its surrounding mesenchyme. Whereas the factors...

... of the epithelial ureteric bud, the primordium of the specialized three-layered inner epithelial lining of the ureter, the urothelium ( Bohnenpoll et al., 2013 ). The mesenchymal cells directly adjacent to the ureteric epithelium (UE) acquire at E12.5 a rhomboid shape, express at E14.5 Myocd , the master regulator...

... for 18 h with DMSO (control), with 10 µg/ml of the BMP4 antagonist noggin, with 100 ng/ml BMP4, with 1 µM of the pan-RAR inhibitor BMS493 or with 1 µM RA. At least three ( n ≥3) independent specimens were analyzed for each assay. k, kidney; nd, nephric duct; rs, renal stroma; u, ureter; ue, ureteric...

... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...

... crosstalk in the murine ureter. Loss of Fgfr2 in the ureteric epithelium led to reduced proliferation, stratification, intermediate and basal cell differentiation in this tissue, and affected cell survival and smooth muscle cell differentiation in the surrounding mesenchyme. Loss of Fgfr2 impacted...

... hybridization analysis on transverse sections of the proximal ureter region at E14.5. a, adrenal; bl, bladder; k, kidney; te, testis; u, ureter; ue, ureteric epithelium; um, ureteric mesenchyme. Fig. 5. Tbx18cre/+;HprtTBX2/y embryos develop uretero-pelvic junction obstruction and exhibit delayed and reduced...

... to the bladder ( Fig. 6 G-J; supplementary material ). The ureters are inserted in a stereotypical position in the trigone, where ureteral muscle and bladder muscle intersect to form the anti-reflux valve ( Carpenter et al., 2012 ; Viana et al., 2007 ) ( Fig. 6 K,L). Fig. 6. Morphology of the bladder...

... in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional obstruction of the ureter. Histological analysis revealed that the layer of undifferentiated mesenchymal cells directly adjacent to the ureteric epithelium did not undergo characteristic cell shape changes...

..., but it fails to initiate branching despite tip-specific expression of Ret and Wnt11 . The stalk-specific marker Wnt9b and the β-catenin downstream target Axin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...

... of urine transport from the renal pelvis to the bladder, often resulting in dilation of the ureter (hydroureter) and renal pelvis (hydronephrosis), which may ultimately lead to renal failure. In mammals, ureter and kidney development begins when an epithelial outgrowth (the ureteric bud, UB) appears...

... differentiation are potentially of great importance for understanding human disease. In the urinary tract, SM is present in the renal pelvis, the ureter, the bladder and the urethra, and is central to the functions of these organs. As in other viscera, ureteric SM develops from local mesenchyme ( Yu et al.,2002...

...-gestation when the ureters move from their primary insertion site in the Wolffian ducts to the trigone, a muscular structure comprising the bladder floor just above the urethra. Precise connections between the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however...

... of the condensed mesenchymal cells into epithelial cells that compose the urinary tubules. The lower part of the ureteric bud elongates out of the metanephric mesenchyme and becomes the ureter. Beside the Wolffian duct, the Müllerian duct (also called the paramesonephric duct) is formed by invagination...

..., ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter— the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic...