...Anna-Carina Weiss; Eva Blank; Tobias Bohnenpoll; Marc-Jens Kleppa; Reginaldo Rivera-Reyes; Makoto Mark Taketo; Mark-Oliver Trowe; Andreas Kispert ABSTRACT The murine kidney and ureter develop in a regionalized fashion from the ureteric bud and its surrounding mesenchyme. Whereas the factors...

... of the epithelial ureteric bud, the primordium of the specialized three-layered inner epithelial lining of the ureter, the urothelium ( Bohnenpoll et al., 2013 ). The mesenchymal cells directly adjacent to the ureteric epithelium (UE) acquire at E12.5 a rhomboid shape, express at E14.5 Myocd , the master regulator...

... of Biologists Ltd 2022 Summary: Gata6 is expressed in the undifferentiated ureteric mesenchyme and its conditional loss leads to hydroureternephrosis in fetal and adult mice revealing its potential use as a candidate for genetic screening for hydroureter. Ureter Smooth muscle cell...

... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...

... crosstalk in the murine ureter. Loss of Fgfr2 in the ureteric epithelium led to reduced proliferation, stratification, intermediate and basal cell differentiation in this tissue, and affected cell survival and smooth muscle cell differentiation in the surrounding mesenchyme. Loss of Fgfr2 impacted...

... -dependent WNT signaling ( Tbx18 cre/+ ;Ctnnb1 (ex3)fl/+ ) and loss of SHH/SMO signaling ( Tbx18 cre/+ ;Smo fl/fl ) in the UM. k, kidney; ue, ureteric epithelium; um, ureteric mesenchyme. Fig. 1. Expression of Tbx2 and Tbx3 during embryonic ureter development. (A,B) RNA in situ hybridization...

...) ( Carpenter et al., 2012 ). The ureters are muscular tubes that transport urine from the renal pelvis to the bladder ( Fig. 6 G-J; supplementary material ). The ureters are inserted in a stereotypical position in the trigone, where ureteral muscle and bladder muscle intersect to form the anti-reflux valve...

... in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional obstruction of the ureter. Histological analysis revealed that the layer of undifferentiated mesenchymal cells directly adjacent to the ureteric epithelium did not undergo characteristic cell shape changes...

..., but it fails to initiate branching despite tip-specific expression of Ret and Wnt11 . The stalk-specific marker Wnt9b and the β-catenin downstream target Axin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...

... impairment of the ureteric smooth muscle (SM) is a common cause of renal dysfunction, leading to a failure of urine transport from the renal pelvis to the bladder, often resulting in dilation of the ureter (hydroureter) and renal pelvis (hydronephrosis), which may ultimately lead to renal failure...

... to the ureteric epithelium participates in the differentiation of the urothelium( Airik et al., 2006 ). To investigate whether loss of Tshz3 in the ureteric mesenchyme would compromise differentiation of the ureteric epithelium, we analysed UPK expression in E18.5 Tshz3 lacZ/lacZ proximal ureters. Expression...

...-gestation when the ureters move from their primary insertion site in the Wolffian ducts to the trigone, a muscular structure comprising the bladder floor just above the urethra. Precise connections between the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however...

.... Recently, Naim et al. reported renal hypoplasia and decreased numbers of ureteric branches in the kidneys of gene-targeted mice lacking the C-terminus of Dlgh1 protein ( Naim et al.,2005 ). In that study, however, no other morphological abnormalities of the ureter and genital tract that resembled those...

..., ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter— the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic...