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Keywords: Ureter
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev199735.
Published: 17 February 2022
... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
... crosstalk in the murine ureter. Loss of Fgfr2 in the ureteric epithelium led to reduced proliferation, stratification, intermediate and basal cell differentiation in this tissue, and affected cell survival and smooth muscle cell differentiation in the surrounding mesenchyme. Loss of Fgfr2 impacted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
... simply reflect the default state of differentiation in the complete absence of SMC progenitors. Tbx2/3cDKO ureters displayed an expansion of expression of genes encoding ECM proteins, particularly collagens and fibulins, into the inner SMC layer of the ureteric wall, and ectopic expression of TBX2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1893–1908.
Published: 15 May 2015
... to the bladder ( Fig. 6 G-J; supplementary material ). The ureters are inserted in a stereotypical position in the trigone, where ureteral muscle and bladder muscle intersect to form the anti-reflux valve ( Carpenter et al., 2012 ; Viana et al., 2007 ) ( Fig. 6 K,L). Fig. 6. Morphology of the bladder...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3099–3108.
Published: 1 September 2012
... in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional obstruction of the ureter. Histological analysis revealed that the layer of undifferentiated mesenchymal cells directly adjacent to the ureteric epithelium did not undergo characteristic cell shape changes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3099–3106.
Published: 15 September 2010
..., but it fails to initiate branching despite tip-specific expression of Ret and Wnt11 . The stalk-specific marker Wnt9b and the β-catenin downstream target Axin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...
Journal Articles
Journal: Development
Development (2010) 137 (5): 755–765.
Published: 1 March 2010
.... W. , Mendoza S. A. , Nigam S. K. ( 2006 ). Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system . Dev. Biol. 298 , 571 - 584 . Cai C. L. , Martin J. C. , Sun Y. , Cui L. , Wang L. , Ouyang...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3301–3310.
Published: 1 October 2008
... visceral SMC differentiation are potentially of great importance for understanding human disease. In the urinary tract, SM is present in the renal pelvis, the ureter, the bladder and the urethra, and is central to the functions of these organs. As in other viscera, ureteric SM develops from local...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3763–3769.
Published: 15 October 2007
...-gestation when the ureters move from their primary insertion site in the Wolffian ducts to the trigone, a muscular structure comprising the bladder floor just above the urethra. Precise connections between the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however...
Journal Articles
Journal: Development
Development (2007) 134 (9): 1799–1807.
Published: 1 May 2007
... the collecting duct system, and differentiation of the condensed mesenchymal cells into epithelial cells that compose the urinary tubules. The lower part of the ureteric bud elongates out of the metanephric mesenchyme and becomes the ureter. Beside the Wolffian duct, the Müllerian duct (also called...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (22): 5301–5312.
Published: 15 November 2002
..., ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter— the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic...