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Keywords: Ubiquitylation
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Reproductive biology
Journal: Development
Development (2021) 148 (14): dev199461.
Published: 16 July 2021
... by the late two-cell stage and then transported to lysosomes for degradation at the later stages. During this process, large amounts of ubiquitylated proteins accumulated on endosomes. Furthermore, the degradation of GlyT1a with mutations in potential ubiquitylation sites was delayed, suggesting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev169797.
Published: 13 December 2018
... interaction between p53 and the zinc-dependent E3 ubiquitin ligase Mdm2, and greatly reduced p53 ubiquitylation. Overexpression of human CHIP, a zinc-independent E3 ubiquitin ligase that targets p53, relieved TPEN-induced p53 stabilization and reduced apoptosis. Expression of p53 pro-apoptotic target genes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev165340.
Published: 3 September 2018
... progenitor domains and affecting interneuron cell fate specification in the developing spinal cord. Ventral spinal cord RNF220 ZC4H2 p2 domain V2 interneuron Ubiquitylation Mouse Chick In the developing ventral spinal cord, progenitor cell populations in each specific progenitor domain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 1 August 2014
... to exclude it from the posterior cortex, thereby removing the cortical anchor for the Par-6/aPKC complex. Slmb is usually recruited to its targets by binding to phosphorylated residues that lie 9-14 amino acids downstream from the ubiquitylated lysine ( Wu et al., 2003 ). Although both aPKC and Par-6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (19): 3600–3612.
Published: 1 October 2012
... neurons ( Fig. 3E,F ). * Author for correspondence ( stegmueller@em.mpg.de ) Competing interests statement The authors declare no competing financial interests. 11 7 2012 © 2012. Cdh1-APC Smurf1 Axon growth Myelin Ubiquitylation Mouse Rat Axon...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (18): 3057–3065.
Published: 15 September 2009
...-houston@uiowa.edu ) 23 7 2009 © 2009. © 2009. 2009 Xenopus Dorsal axis Wnt Microtubules Cortical rotation Trim Ubiquitylation Understanding the establishment of the embryonic body axis from a symmetrical egg has been a long-standing problem in developmental biology...
Includes: Multimedia, Supplementary data