... by monoubiquitylating DLX3. Our findings suggest that the two E3 ubiquitin ligases CHIP and MDM2 reciprocally regulate DLX3 activity by catalyzing distinct types of ubiquitylation, and reveal an important mechanism by which differentiation of odontoblasts is delicately regulated by divergent post-translational...

... by the late two-cell stage and then transported to lysosomes for degradation at the later stages. During this process, large amounts of ubiquitylated proteins accumulated on endosomes. Furthermore, the degradation of GlyT1a with mutations in potential ubiquitylation sites was delayed, suggesting...

... interaction between p53 and the zinc-dependent E3 ubiquitin ligase Mdm2, and greatly reduced p53 ubiquitylation. Overexpression of human CHIP, a zinc-independent E3 ubiquitin ligase that targets p53, relieved TPEN-induced p53 stabilization and reduced apoptosis. Expression of p53 pro-apoptotic target genes...

... in modulating various signaling pathways by adding a ubiquitin moiety to the target protein for downstream signal transduction, without degrading target proteins. For example, mind bomb 1 (Mib1) is an E3 ubiquitin ligase that ubiquitylates delta and promotes its internalization, which is essential...

... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Axis formation Par-1 SCF Ubiquitylation Apical-basal polarity Oskar In C. elegans and Drosophila , the anterior-posterior (AP) axis is defined through the formation...

.... , Flatau G. , et al . ( 2006 ). CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1–/– cells . Mol. Biol. Cell 17 , 2489 – 2497 . Bryan B. , Cai Y. , Wrighton K. , Wu G. , Feng X. H. , Liu M. ( 2005 ). Ubiquitination...

[email protected] ) 23 7 2009 © 2009. © 2009. 2009 Xenopus Dorsal axis Wnt Microtubules Cortical rotation Trim Ubiquitylation Understanding the establishment of the embryonic body axis from a symmetrical egg has been a long-standing problem in developmental biology...