.... Together, two enzymes, tyrosine hydroxylase (TH,encoded by ple ) and dopa decarboxylase (DDC, encoded by Ddc ), produce the dopamine that is required for tanning. Levels of both the ple and Ddc transcripts begin to accumulate before eclosion, coincident with the onset of pigmentation of the pharate adult...

... Chemistry,Martin-Luther-University, Hollystrasse 1, D-06097 Halle, Germany 8 8 2006 © 2006. 2006 Zebrafish Hand2 Tyrosine hydroxylase Dopamine β-hydroxylase Phox2b Gata2 The autonomic nervous system controls body function homoeostasis in vertebrates and is essential...

... chromaffin cells and sympathetic neurons. Additionally, mRNA analyses of purified chromaffin cells from Gata3 mutants show that levels of Mash1, Hand2 and Phox2b(postulated upstream regulators of Gata3) as well as terminally differentiated SA lineage products (tyrosine hydroxylase, Th, and dopamineβ...

... abnormalities in the ventral midbrain. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 25 11 2005 ©2006. 2006 Parkinson's disease Proneural genes Differentiation Midbrain Tyrosine hydroxylase Mouse...

...-catenin overexpression either alone or in association with RA express the caudal neuronal marker Hoxc4. However, RA treatment inhibits the β-catenin-mediated generation of tyrosine hydroxylase-positive neurons, suggesting that not all of the effects of RA are dependent upon β-catenin signaling...

... or the more generic process of neuronal differentiation itself. In gain-of-function experiments, Nurr1 is able to activate transcription of the tyrosine hydroxylase gene by binding a response element within a region of the tyrosine hydroxylase promoter necessary for midbrain-specific expression...

... ) by single label immunocytochemistry. At this stage, the epithe-lial layer also contained cells that expressed immunoreac-tive glucagon (GLU + ) and tyrosine hydroxylase (TH + ) (not shown). The number of IN-CP + cells (3±1.41, n =5) per pancreas was significantly lower than the number of GLU + or TH...

...Guoping Fan; David M. Katz ABSTRACT Although some sensory ganglion cells in mature animals are catecholaminergic, most mammalian sensory neurons that express the catecholamine-synthesizing enzyme tyrosine hydroxylase (TH) do so only transiently during early gangliogenesis in vivo. The lack of TH...

... properties when they terminally differentiate. In the current experiments, segments of fetal mouse gut were explanted before (day E9) TC cells or any neural markers could be detected in situ . Tyrosine hydroxylase (TH)-immuno-reactive neurons developed in vitro in 4/12 such explants; therefore, cells...

... of enteric neuronal diversity, we examined the expression of serotonin (5-HT), tyrosine hydroxylase and GABA in vitro . In the mature avian intestine, intrinsic neurones contain 5- HT or GABA but not tyrosine hydroxylase. These markers were demonstrated immunocytochemically, singly or simultaneously. All...

... the levels of the adrenergic marker enzyme tyrosine hydroxylase. Both total tyrosine hydroxylase activity and protein levels in sympathetic chains were reduced by about 30 % in embryos treated with 27/21 antibody but not in embryos treated with a control antibody. The 27/21 antibody cross-reacts with chick...

... neurotransmitter tyrosine hydroxylase mRNA nerve growth factor NGF sympathetic neurone rat choline acetyltransferase During development, certain eukaryotic genes are regulated at the level of transcription. In addition, a growing number of genes are known, the primary transcripts of which can...