...-producing cells before birth, with the exception of corticotrophs. Of note, Sox2 + stem cells and clonogenic potential are drastically increased in the mutant pituitaries. Finally, we reveal that papillary craniopharyngioma (PCP), a benign human pituitary tumour harbouring BRAF p.V600E also contains Sox2...

... in which parthenogenesis and tumourigenesis follow full meiotic maturation and are linked to fertilisation by PLCZ1. 8 8 2007 © 2007. 2007 Phospholipase C-zeta (PLCZ1) Oocyte activation Fertilisation Tumour Embryo Transgene Mammalian oocytes are typically arrested at meiotic...

... development. Here we use mosaic analysis with a repressible cell marker (MARCM) to study the role of the brain tumor (brat) gene in neural proliferation control and tumour suppression in postembryonic brain development of Drosophila . Our findings indicate that overproliferation in brat mutants is due to loss...

...Adrian W. Moore; Lesley McInnes; Jordan Kreidberg; Nicholas D. Hastie; Andreas Schedl The Wilms’ Tumour gene WT1 has important functions during development. Knock-out mice were shown to have defects in the urogenital system and to die at embryonic day E13.5, probably due to heart failure. Using...