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Keywords: Tumour
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Journal Articles
Journal: Development
Development (2017) 144 (12): 2141–2152.
Published: 15 June 2017
...-producing cells before birth, with the exception of corticotrophs. Of note, Sox2 + stem cells and clonogenic potential are drastically increased in the mutant pituitaries. Finally, we reveal that papillary craniopharyngioma (PCP), a benign human pituitary tumour harbouring BRAF p.V600E also contains Sox2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3941–3952.
Published: 01 November 2007
...-represented for paternally- and placentally-expressed transcripts. Plcz1 was not overexpressed in the ovaries of LT/Sv or in human germline ovarian tumours. The narrow spectrum of PLCZ1 activity indicates that it is modulated by tissue-restricted accessory factors. This work characterises a novel model in...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2639–2648.
Published: 15 July 2006
... development. Here we use mosaic analysis with a repressible cell marker (MARCM) to study the role of the brain tumor ( brat ) gene in neural proliferation control and tumour suppression in postembryonic brain development of Drosophila . Our findings indicate that overproliferation in brat mutants is due to...