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Keywords: Tumorigenesis
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Journal Articles
Journal: Development
Development dev.200932.
Published: 24 January 2023
...-deleted model were similar to the features of enterocolitis, such as shortened intestines, decreased numbers of goblet cells and Paneth cells, and severe inflammation. Additionally, loss of Fzd7 exacerbated the defects in a chemical-induced colitis model and could initiate tumorigenesis. These findings...
Journal Articles
Journal: Development
Development (2021) 148 (7): dev196956.
Published: 31 March 2021
... is required for its function in polarity and tumorigenesis, but the exact mechanisms targeting Dlg to the PM remain to be fully elucidated. Here, we show that, similar to recently discovered polybasic polarity proteins such as Lgl and aPKC, Dlg also contains a positively charged polybasic domain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2570–2583.
Published: 15 July 2017
...Noemí Rives-Quinto; Maribel Franco; Ana de Torres-Jurado; Ana Carmena Over the past decade an intriguing connection between asymmetric cell division, stem cells and tumorigenesis has emerged. Neuroblasts, which are the neural stem cells of the Drosophila central nervous system, divide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4883–4894.
Published: 1 November 2005
... Drosophila SMAD genes TGFβ Tumorigenesis Pancreatic cancer Colon cancer Signaling molecules of the Transforming Growth Factor-β (TGFβ)family regulate differentiation and proliferation in many species. Four TGFβ proteins have been characterized in Drosophila and each of these has a counterpart...