... of tunicamycin-induced tumorigenesis. Fig. 3. The EMC associates with Hpo. (A) Co-immunoprecipitation (co-IP) results of EMC1-Flag and Hpo-GFP in S2R+ cells. Lysate from untransfected cells was used as negative control (NC; the same sample as in B). (B) Co-IP results of EMC1-GFP and Hpo-Flag...

... in our Fzd7-deleted model were similar to the features of enterocolitis, such as shortened intestines, decreased numbers of goblet cells and Paneth cells, and severe inflammation. Additionally, loss of Fzd7 exacerbated the defects in a chemical-induced colitis model and could initiate tumorigenesis...

... is required for its function in polarity and tumorigenesis, but the exact mechanisms targeting Dlg to the PM remain to be fully elucidated. Here, we show that, similar to recently discovered polybasic polarity proteins such as Lgl and aPKC, Dlg also contains a positively charged polybasic domain...

...Noemí Rives-Quinto; Maribel Franco; Ana de Torres-Jurado; Ana Carmena Over the past decade an intriguing connection between asymmetric cell division, stem cells and tumorigenesis has emerged. Neuroblasts, which are the neural stem cells of the Drosophila central nervous system, divide...

... School of Medicine, Seattle, WA 98195, USA 18 8 2005 ©2005. 2005 Drosophila SMAD genes TGFβ Tumorigenesis Pancreatic cancer Colon cancer Signaling molecules of the Transforming Growth Factor-β (TGFβ)family regulate differentiation and proliferation in many species...