.... In summary, our evidence points to a novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/β-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity. * Author for correspondence ( [email protected] ) Competing interests statement The authors...

... is organized in collaboration with neoplastic tumor suppressors Discs large and Lethal-giant-larvae, directs cluster asymmetry essential for timing delamination from the epithelium. Fas2-mediated communication between polar and border cells maintains localization of Discs large and Lethal-giant-larvae...

... present biochemical and genetic evidence that loss of the homolog of the tumor suppressor gene, Pten , results in increased PtdIns P 3 levels and that these increased levels are sufficient to compensate for the complete loss of the Insulin/insulin-like growth factor receptor function. This reduction...

... for identifying and studying potential tumor suppressors. One of the identified genes, lats , has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with three proteins in budding yeast and Neu-rospora that are involved in regulation of the cell cycle and growth...

... © 1993 by Company of Biologists 1993 Drosophila imaginal disc tumor suppressor expanded gene SH3-binding site cell proliferation Imaginal discs are the progenitors of adult integument in holometabolous insects. They consist of a single-cell layer epithelium that arises...