... Summary: Commensal Lactobacillus brevis disrupts progenitor cell adhesion, promotes symmetric stem cell divisions and stimulates tumor growth in the Drosophila intestine. Stem cells Microbiome Tumor Integrins Intestine Immunity To maintain an effective barrier to invasion by gut...

... the Drosophila neoplastic tumor suppressors . Genes Dev. 18 , 1909 - 1925 . 10.1101/gad.1211604 Bilder D. , Li M. , Perrimon N. ( 2000 ). Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors . Science 289 , 113 - 116 . 10.1126/science.289.5476.113...

.... 19 2 2012 © 2012. Germline Repression Stem cells Translation Tumor Drosophila Understanding the mechanisms that control the balance between stem cell self-renewal and differentiation is one of the fundamental goals of stem cell biology. This balance often...

... differentiation are coordinated during this transition. Here, we demonstrate that the Arabidopsis thaliana RETINOBLASTOMA-RELATED protein (RBR) ortholog of the animal tumor suppressor retinoblastoma (pRB) not only controls the expression of cell cycle-related genes, but is also required for persistent shut-down...

... neuroepithelia. Mutation of tumor suppressor genes within the pathway, or expression of activated Yorkie, promotes overgrowth of neuroepithelial cells and delays or blocks their differentiation; mutation of yorkie inhibits growth and accelerates differentiation. Neuroblasts and other neural cells, by contrast...

... for correspondence (e-mail: [email protected] ) * Present address: Neuroscience Department, University of Florida, 100 Newell Dr Rm L1-100 Gainesville, Fl 23610, USA 13 5 2005 ©2005. 2005 Gli Neurogenesis Tumor Morpholino Neural plate Xenopus Antisense...

[email protected] ) 13 10 2003 © 2004. 2004 Germline development Stem cells Proliferation Tumor Meiotic entry Notch signaling gld-1 nos-3 glp-1 Stem cells are of intense interest because of their potential use in regenerative medicine ( Daley,2002 ; Pfendler and Kawase...

... role in the cerebellum, our findings indicate that SHH signaling unexpectedly controls the development of the three major dorsal brain structures. We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor...

... and vertebrate Notch family members can lead to tumor formation. * Author for correspondence (e-mail: [email protected] ) 07 11 1996 © 1997 by Company of Biologists 1997 The molecular lesion responsible for the glp-1(oz112gf) phenotypes is a missense mutation (Ser642Asp) located...

... in a variety of kidney tumors. Yet, little is known about the signals regulating this transient expression pattern in the developing kidney. We have examined the spatial and temporal expression patterns of Pax-2 and the Wilms’ tumor suppresser protein WT1 with specific antibodies in developing mouse kidneys...

...Stefan Mundlos; Jerry Pelletier; André Darveau; Michael Bachmann; Andreas Winterpacht; Bernhard Zabel ABSTRACT The human Wilms’ tumor gene WT1 encodes a putative transcription factor implicated in tumorigenesis and in specifying normal urogenital development. We have studied the distribution of WT1...

... 1993 © 1993 by Company of Biologists 1993 CRABP I cataract retinoic acid mouse eye lens pancreas tumor fibre differentiation Retinoic acid plays an important role during embryonic development of vertebrates ( Tickle et al., 1982 ; Durston et al., 1989 ). Vitamin A is also...

... for both genes during glomeruli maturation. Using somatic cell hybrids, we assigned the PAX8 gene to human chromosome 2. Comparative mapping data suggest a localization on distal 2q. © 1992 by Company of Biologists 1992 paired box human PAX8 human chromosome 2q Wilms’ tumor A number...