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Keywords: Tumor
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev186106.
Published: 09 March 2021
... pathways that drive stem cell divisions. In a Notch-deficient background, L. brevis -mediated proliferation causes rapid expansion of mutant progenitors, leading to accumulation of large, multi-layered tumors throughout the midgut. Mechanistically, we showed that L. brevis disrupts expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2978–2983.
Published: 01 August 2014
... ubiquitin ligase, cause dramatic loss of polarity in imaginal discs accompanied by tumorous proliferation defects. Slmb function is required to restrain apical aPKC activity in a manner that is independent of endolysosomal trafficking and parallel to the Scribble module of junctional scaffolding proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1547–1556.
Published: 01 May 2012
... away from the cap cells, they formed tumorous multicellular cysts ( Fig. 1G ). We never observed transient mei-P26 mutant germline clones giving rise to normal egg chambers, suggesting that the mei-P26 phenotypes in GSCs and differentiating cysts are independent from one another. These data provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2977–2986.
Published: 15 July 2011
... differentiation are coordinated during this transition. Here, we demonstrate that the Arabidopsis thaliana RETINOBLASTOMA-RELATED protein (RBR) ortholog of the animal tumor suppressor retinoblastoma (pRB) not only controls the expression of cell cycle-related genes, but is also required for persistent shut-down...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2397–2408.
Published: 15 July 2010
... neuroepithelia. Mutation of tumor suppressor genes within the pathway, or expression of activated Yorkie, promotes overgrowth of neuroepithelial cells and delays or blocks their differentiation; mutation of yorkie inhibits growth and accelerates differentiation. Neuroblasts and other neural cells, by contrast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3267–3279.
Published: 15 July 2005
... the possible factors that associate. The cooperative and combinatorial function of Gli proteins may also be critical in cancer (e.g. Ruiz i Altaba et al., 2004 ) as endogenous Gli1 has been shown to be required for the induction of epidermal and neural tumors by exogenous GLI1( Dahmane et al., 1997...
Journal Articles
Journal: Development
Development (2004) 131 (1): 93–104.
Published: 01 January 2004
...@genetics.wustl.edu ) 13 10 2003 © 2004. 2004 Germline development Stem cells Proliferation Tumor Meiotic entry Notch signaling gld-1 nos-3 glp-1 Stem cells are of intense interest because of their potential use in regenerative medicine ( Daley,2002 ; Pfendler and Kawase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (24): 5201–5212.
Published: 15 December 2001
... role in the cerebellum, our findings indicate that SHH signaling unexpectedly controls the development of the three major dorsal brain structures. We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor...