... inactivation and reactivation. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. Tsix X chromosome inactivation XCI activator XCI inhibitor Xist The evolution...

.... Interestingly, the normally silent paternal copy of Tsix , which is an antisense negative regulator of Xist ,was ectopically activated in the preimplantation embryo. Furthermore, CpG sites in the promoter region of paternal Xist , which are essentially unmethylated in the extraembryonic tissues of the wild-type...

... antisense gene, Tsix , whose transcripts (though a fraction of them stay unspliced),are processed like common proteincoding RNAs. It has been suggested that certain classes of sense-antisense pairs of RNA are causally involved in not only gene regulation but also higher order chromatin structure in various...

...Takashi Sado; Zhenjuan Wang; Hiroyuki Sasaki; En Li ABSTRACT In mammals, X-chromosome inactivation is imprinted in the extra-embryonic lineages with paternal X chromosome being preferentially inactivated. In this study, we investigate the role of Tsix , the antisense transcript from the Xist locus...