..., and ultimately TRP53-dependent apoptosis. Trp53 -deficient spermatogonial stem cells exhibited karyotype defects, but proliferated normally despite reduced CDKN1C and AURKB expression. In contrast, Aurkb depletion upregulated TRP53 and CDKN1C, suggesting a negative feedback loop to maintain euploidy. Thus...

... ligase Trp53 National Heart, Lung, and Blood Institute 10.13039/100000050 R01 HL142215 HL143256 HL122406 HL119946 The respiratory primordium initiates with the emergence of a small cluster of progenitors in the anterior ventral foregut, marked by their expression...

... acetylation NOC2-like nucleolar associated transcriptional repressor Trp53 Trp63 European Research Council 10.13039/100010663 322844 Deutsche Forschungsgemeinschaft 10.13039/501100001659 SFB 992 SFB 850 SFB 746 The epidermis is a complex tissue formed from embryonic...

... in the cortex. Microcephaly Tubulin Apoptosis Trp53 The generation of the mammalian neocortex relies on a functional microtubule cytoskeleton ( Ayala et al., 2007 ; Kuijpers and Hoogenraad, 2011 ). Microtubules mediate the separation of sister chromatids in neuronal progenitors, translocate...

... of tissue and cancer stem cell self-renewal. p53 Self-renewal Stem cell p21 (Cdkn1a) Adult Cancer Mouse Trp53 Microarray data A hallmark feature of stem cells in the adult is their capacity to self-renew over the lifespan of the organism. The extensive self-renewal...