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Keywords: Trophoblast stem cell
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Journal Articles
Journal: Development
Development (2018) 145 (19): dev162644.
Published: 1 October 2018
... trophoblast stem cells (TSCs), TEAD4 localizes to mitochondria, binds to mitochondrial DNA (mtDNA) and facilitates its transcription by recruiting mitochondrial RNA polymerase (POLRMT). Loss of TEAD4 impairs recruitment of POLRMT, resulting in reduced expression of mtDNA-encoded electron transport chain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (22): 4480–4489.
Published: 15 November 2013
... lineage. Parthenogenetic trophoblast stem cells (TSCs) are extremely difficult to derive, suggesting that an imprinted gene(s) is necessary for TSC establishment or maintenance. In a candidate study, we were able to narrow the list to one known paternally expressed gene, Sfmbt2. We show that mouse embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3827–3836.
Published: 1 November 2007
... embryos. Tead4 -/- embryos do not express trophectoderm-specific genes, such as Cdx2 , but do express ICM-specific genes, such as Oct4 (also known as Pou5f1 ). Consequently, Tead4 -/- morulae do not produce trophoblast stem cells,trophectoderm or blastocoel cavities, and therefore do not implant...
Journal Articles
Journal: Development
Development (2002) 129 (16): 3913–3924.
Published: 15 August 2002
... of fibroblast growth factor 4-dependent trophoblast stem cell potential. Two post-implantation derivatives of the polar trophectoderm – early-streak extra-embryonic ectoderm and late-streak chorionic ectoderm – were microdissected into fractions along their proximodistal axis and thoroughly dissociated...