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Keywords: Trophectoderm
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Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
... for trophectodermal Tat-Cre/loxP recombination. We used the natural permeability barrier in mouse blastocysts in combination with off-the-shelf Tat-Cre recombinase to achieve editing of conditional alleles in the trophoblast lineage. This direct approach enables gene function analysis during implantation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3151–3165.
Published: 15 September 2015
... NANOG expression in human epiblast cells, consistent with a requirement for this pathway in pluripotency. Although the key trophectoderm factors Id2 , Elf5 and Eomes are exclusively localized to this lineage in the mouse, the human orthologues are either absent or expressed in alternative lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2586–2597.
Published: 1 August 2015
... how the chromatin remodelling protein CHD4 facilitates the first lineage decision in mammalian embryogenesis. Embryos lacking CHD4 can form a morphologically normal early blastocyst, but are unable to successfully complete the first lineage decision and form functional trophectoderm (TE...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2279–2288.
Published: 1 June 2014
...Tomoko Watanabe; John S. Biggins; Neeta Bala Tannan; Shankar Srinivas The formation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events during mammalian embryogenesis. It is believed that the orientation of division of polarised blastomeres in the 8- and 16...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1140–1150.
Published: 1 March 2014
... outer trophectoderm (TE) and internal primitive endoderm (PE) in the blastocyst and subsequently give rise to chorio-allantoic and visceral yolk sac placentae, respectively. We have shown maternal low protein diet exclusively during mouse preimplantation development (Emb-LPD) is sufficient to cause...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3680–3690.
Published: 1 September 2013
...Kotaro J. Kaneko; Melvin L. DePamphilis It has been suggested that during mouse preimplantation development, the zygotically expressed transcription factor TEAD4 is essential for specification of the trophectoderm lineage required for producing a blastocyst. Here we show that blastocysts can form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (21): 3969–3972.
Published: 1 November 2012
...@biology.ucsc.edu ) Competing interests statement The authors declare no competing financial interests. 14 8 2012 © 2012. 2012 Blastocyst Maternal-effect gene Trophectoderm Caudal In animals, early embryonic development is regulated by maternal genes, which are transcribed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 3–14.
Published: 1 January 2012
... and the trophectoderm. Shortly after implantation, the anterior-posterior axis is firmly established. Recent studies have provided a better understanding of how the earliest cell fate decisions are regulated in the pre-implantation embryo, and how and when the body axes are established in the pregastrulation embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4159–4169.
Published: 15 December 2010
...Guangming Wu; Luca Gentile; Takuya Fuchikami; Julien Sutter; Katherina Psathaki; Telma C. Esteves; Marcos J. Araúzo-Bravo; Claudia Ortmeier; Gaby Verberk; Kuniya Abe; Hans R. Schöler The separation of the first two lineages – trophectoderm (TE) and inner cell mass (ICM) – is a crucial event...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 3953–3963.
Published: 1 December 2010
...-implantation embryo. Here, we show that Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endoderm (PE) development. Although cell polarity appeared normal, Klf5 mutant embryos arrested at the blastocyst stage and failed to hatch due...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3383–3391.
Published: 15 October 2010
...Robert Odell Stephenson; Yojiro Yamanaka; Janet Rossant The first two cell lineages in the mouse, the surface trophectoderm (TE) and inner cell mass (ICM), are morphologically distinguishable by E3.5, with the outer TE forming a polarized epithelial layer enclosing the apolar ICM. We show here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (3): 395–403.
Published: 1 February 2010
... 2010. 2010 Trophectoderm Placenta Implantation Pluripotency Lineage restriction Embryogenesis Mouse The first developmental decisions during mouse development lead to the establishment of the embryonic and extraembryonic tissue lineages. Stem cell lines have been isolated from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (7): 1295–1305.
Published: 1 April 2003
... to facilitate or to suppress cell-cycle progression. In stark contrast to the milder phenotypes that result from inactivation of E2Fs, we report that loss of Dp1 leads to death in utero because of the failure of extra-embryonic development. Loss of Dp1 compromises the trophectoderm-derived tissues...
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (10): 2027–2037.
Published: 15 May 1997
...Bhavwanti Sheth; Ira Fesenko; Jane E. Collins; Breda Moran; Arthur E. Wild; James M. Anderson; Tom P. Fleming ABSTRACT The mouse preimplantation embryo has been used to investigate the de novo synthesis of tight junctions during trophectoderm epithelial differentiation. We have shown previously...
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (3): 743–753.
Published: 1 March 1995
.... Previously, we have shown that desmocollin protein synthesis is undetectable in eggs and cleavage stages but initiates at the early blastocyst stage when desmocollin localises at, and appears to regulate assembly of, nascent desmosomes that form in the trophectoderm but not in the inner cell mass (Fleming, T...
Journal Articles
Journal: Development
Development (1994) 120 (11): 3289–3299.
Published: 1 November 1994
...Catherine Gueth-Hallonet; Angelica Santa-Maria; Pierre Verroust; Bernard Maro ABSTRACT During preimplantation development of the mouse embryo, a layer of outer cells differentiates into a perfect epithelium, the trophectoderm. The divergence between the trophectoderm and the inner cell mass takes...
Journal Articles
Journal: Development
Development (1993) 117 (3): 1145–1151.
Published: 1 March 1993
... in the absence of extracellular calcium. Cingulin synthesis is also tissue-specific in blastocysts, being up-regulated in trophectoderm and down-regulated in the inner cell mass. Taken together, the results suggest that (i) cingulin may have a role during oogenesis and (ii) cell-cell contact patterns regulate...