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Keywords: TrkC
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Journal Articles
Journal: Development
Development (2007) 134 (24): 4369–4380.
Published: 15 December 2007
...-mediated signaling through Trk tyrosine kinase receptors is important for embryonic cortical precursor cell development. These studies demonstrate that inhibition of TrkB (Ntrk2)and/or TrkC (Ntrk3) signaling using dominant-negative Trk receptors, or genetic knockdown of TrkB using shRNA, caused a decrease...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (2): 321–330.
Published: 15 January 2003
.... However, it is not yet clear when, and in what order, crest cells become specified to adopt a particular fate. We report that the receptor tyrosine kinases TrkC and C-Kit are expressed by distinct neural crest subpopulations in vitro. We then analyzed the lineages of individual receptor-expressing crest...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4315–4327.
Published: 1 November 2001
... (NT3) ablation in mice causes a more severe neuronal phenotype than deletion of its receptor TrkC, suggesting that NT3 acts also through other non-preferred Trk receptors. To study the role of low-affinity ligand receptor interactions in vivo, we have replaced the Nt3 gene with the gene for brain...
Journal Articles
Journal: Development
Development (2001) 128 (3): 417–426.
Published: 1 February 2001
..., reflecting a profound deafness. DiI fiber staining, immunostaining and cell death assays reveal that the deafness is due to the failure of inner ear sensory neuron survival during development. The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1995) 121 (5): 1341–1350.
Published: 1 May 1995
... period of sensory neuron death in vivo. * Author for correspondence 15 02 1995 © 1995 by Company of Biologists 1995 neurotrophin-3 muscle spindle afferents cutaneous afferents motoneurons trkC cell death During normal embryonic development, approximately half...
Journal Articles
Journal: Development
Development (1993) 118 (2): 463–475.
Published: 1 June 1993
... for NGF function ( Loeb et al., 1991 ) and forms part of the high affinity NGF receptor ( Klein et al., 1991 ; Hempstead et al., 1991 ). Furthermore, the NGF-related neurotrophins have been identified as ligands for the Trk -related RTK-encoding genes trkB and trkC ( Berkemeier et al., 1991 ; Ip et...