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Keywords: TrkB
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Journal Articles
Journal: Development
Development (2010) 137 (23): 4005–4015.
Published: 1 December 2010
... in the involvement of intracellular regulators of RTK signalling in multicellular and unicellular branching. BDNF Sprouty TrkB Xenopus Branching Motoneuron The establishment of correct neuronal connections, also known as neuronal wiring, is crucial for the function of the nervous system...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4369–4380.
Published: 15 December 2007
...-mediated signaling through Trk tyrosine kinase receptors is important for embryonic cortical precursor cell development. These studies demonstrate that inhibition of TrkB (Ntrk2)and/or TrkC (Ntrk3) signaling using dominant-negative Trk receptors, or genetic knockdown of TrkB using shRNA, caused a decrease...
Journal Articles
Journal: Development
Development (2003) 130 (19): 4741–4750.
Published: 1 October 2003
... of the mature cochlea is currently unknown. Here, we have analysed the consequences of a lack of the TrkB receptor and its ligand, the neurotrophin brain-derived neurotrophic factor (Bdnf), in the late postnatal or adult cochlea using mouse mutants. During early postnatal development, mutant animals show a lack...
Journal Articles
Journal: Development
Development (2003) 130 (15): 3535–3545.
Published: 1 August 2003
... / Nt3 null mutant mice;and (2) the lack of survival-promoting effects of GDNF and/or NT3 in rat E13.5 primary cultures. In contrast, null mutant mice for TrkB, the tyrosine kinase receptor for brain-derived neurotrophic factor and neurotrophin 4, displayed a clear loss of locus coeruleus noradrenergic...
Journal Articles
Journal: Development
Development (2003) 130 (3): 611–622.
Published: 1 February 2003
.... To dissociate retrograde and anterograde effects of the TrkB ligands, we analyzed the stratum griseum superficiale (SGS) of the superior colliculus, a target of visual cortical efferents. Indeed, TrkB-expressing inhibitory SGS neurons responded to cortical NT-4/5 infusion with somatic growth. Strikingly...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4315–4327.
Published: 1 November 2001
...-derived neurotrophic factor (BDNF), a TrkB ligand. As in NT3 and TrkC null mice, the proprioception system of these mutants failed to assemble. However, sensory fiber projections in the embryonic spinal cord suggest chemotropic effects of BDNF in vivo. In the dorsal root ganglia, the developmental dynamic...