...Vincenzo Coppola; Colleen A. Barrick; Eileen A. Southon; Arkady Celeste; Kathryn Wang; Bei Chen; El-Bdaoui Haddad; Jian Yin; Andre Nussenzweig; Arun Subramaniam; Lino Tessarollo The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions...

...Long Ma; Lei Lei; S. Raisa Eng; Eric Turner; Luis F. Parada The TrkA/NGF receptor is essential for the survival and differentiation of sensory neurons. The molecular mechanisms regulating tissue and stage-specific expression of TrkA are largely unknown. The Brn3a POU-domain transcription factor has...

... of neurotrophin-deprived neurones. To further examine this assertion in vivo, we have studied two populations of NGF-dependent neurones during the period of naturally occurring neuronal death in mice that lack BAX, NGF or the NGF receptor TrkA, alone and in combination. In the superior cervical ganglion (SCG...

... of neuron numbers demonstrates that NT3 is required for activation of TrkB during neurogenesis and that TrkA is required during target tissue innervation. In the inner ear, the ectopic BDNF rescued the severe neuronal deficits caused by NT3 absence, indicating that TrkB and TrkC activate equivalent pathways...