... Polycomb Trithorax Österreichischen Akademie der Wissenschaften 10.13039/501100001822 Austrian Science Fund 10.13039/501100002428 Z_153_B09 European Research Council 10.13039/100010663 During development of the central nervous system (CNS), neural stem cells...

.... However, analysis of embryos homozygous for a targeted mutation of Aebp2 unexpectedly revealed a Trithorax phenotype, normally linked to antagonism of Polycomb function. Consistent with this, we observe elevated levels of PRC2-mediated histone H3K27 methylation at target loci in Aebp2 mutant embryonic...

...Feng Tie; Rakhee Banerjee; Alina R. Saiakhova; Benny Howard; Kelsey E. Monteith; Peter C. Scacheri; Michael S. Cosgrove; Peter J. Harte Trithorax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-dependent transcription, and establishes a ‘cellular memory...

... classifies Utx as a trithorax group regulator. We propose that Utx is needed in the early embryo to prevent inappropriate instalment of long-term Polycomb repression at HOX genes in cells in which these genes must be kept active. In contrast to PRC2, which is essential for, and continuously required during...

...Ming Fang; Hongyan Ren; Jiabin Liu; Ken M. Cadigan; Sanjeevkumar R. Patel; Gregory R. Dressler Development of the fruit fly Drosophila depends in part on epigenetic regulation carried out by the concerted actions of the Polycomb and Trithorax group of proteins, many of which are associated...

...Svetlana Petruk; Sheryl T. Smith; Yurii Sedkov; Alexander Mazo Polycomb group (PcG) and trithorax group (trxG) proteins act in an epigenetic fashion to maintain active and repressive states of expression of the Hox and other target genes by altering their chromatin structure. Genetically, mutations...

...Shrividhya Srinivasan; Jennifer A. Armstrong; Renate Deuring; Ina K. Dahlsveen; Helen McNeill; John W. Tamkun The Drosophila trithorax group gene kismet ( kis )was identified in a screen for extragenic suppressors of Polycomb ( Pc ) and subsequently shown to play important roles in both...

... trithorax trithoraxgleich zinc finger homeodomain protein-1 Mesoderm Cell migration Cellular movements play a crucial role in the development of a multicellular organism. They can serve a variety of functions ranging from creating different tissue layers during gastrulation to the processes...

... distribution of E(Z) protein and discuss their implications concerning putative functional domains. Finally, we describe the effect a trithorax mutation has on E(Z) chromosome binding. * Author for correspondence (e-mail: [email protected] ) 22 08 1996 © 1996 by Company of Biologists 1996...

... wing surfaces. This effect is one of the somatic clone phenotypes of trithorax ( trx ) lethals. A similar dorsal-to-ventral transformation is observed in Pc Dlw/Dlw clones. Dlw 1 /Dlw 1 clones have no effect elsewhere, except in the dorsal notum, which may differentiate extra macrochaetes. We propose...

...Yurii Sedkov; Sergei Tillib; Lev Mizrokhi; Alexander Mazo ABSTRACT The trithorax gene is required throughout development to maintain expression of homeotic genes of the bithorax and Antennapedia complexes. We determined complete structures of maternal and zygotic alternatively spliced trithorax...

...T. R. Breen; P. J. Harte ABSTRACT The trithorax ( trx ) gene is required for normal development of the body plan in Drosophila embryos and adults. Mutations in trx cause homeotic transformations throughout the body. Genetic studies suggest that trx encodes a positive regulatory factor required...

...P. W. Ingham ABSTRACT The requirement for the trithorax gene during imaginal cell proliferation has been analysed by clonal analysis. Clones carrying the allelic Regulator of bithorax and trithorax mutations were induced by mitotic recombination at different developmental stages. The results...