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Keywords: Translation
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Journal Articles
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Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199560.
Published: 29 October 2021
...Mansour Aboelenain; Karen Schindler ABSTRACT Mammalian oocytes are transcriptionally quiescent, and meiosis and early embryonic divisions rely on translation of stored maternal mRNAs. Activation of these mRNAs is mediated by polyadenylation. Cytoplasmic polyadenylation binding element 1 (CPEB1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev196121.
Published: 15 April 2021
... being detected at the posterior of the expression domain in nc14 ( Fig. 7 A). SunTag-hb mRNAs are still present in the anterior in nc14, but ∼95% are not being translated, suggesting that they are being translationally repressed. Fig. 7. Hypothesis for the interplay between transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 8 January 2018
... Translation Parkinson's disease (PD) is a debilitating neurodegenerative movement disorder resulting from progressive loss of dopaminergic (DA) neurons in the midbrain. The relatively focal degeneration makes it a good candidate for cell-based therapies. Since the first clinical trials using fetal...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1201–1210.
Published: 1 April 2017
...Nathalie Oulhen; S. Zachary Swartz; Jessica Laird; Alexandra Mascaro; Gary M. Wessel Stem cells in animals often exhibit a slow cell cycle and/or low transcriptional activity referred to as quiescence. Here, we report that the translational activity in the primordial germ cells (PGCs) of the sea...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 12–16.
Published: 1 January 2017
... Human Organoid Pluripotency Translation Inspired by the success of the first meeting two years ago, Development and The Company of Biologists held the second ‘From Stem Cells to Human Development’ meeting in September 2016 in historic Southbridge (Massachusetts, USA). From the first human...
Journal Articles
Journal: Development
Development (2015) 142 (11): 1960–1970.
Published: 1 June 2015
... is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 3951–3963.
Published: 1 October 2013
... of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation...
Journal Articles
Journal: Development
Development (2012) 139 (9): 1547–1556.
Published: 1 May 2012
... receptor Tkv in cystoblasts ( Casanueva and Ferguson, 2004 ; Xia et al., 2010 ). The TRIM-NHL domain protein Brat also functions in cystoblasts, serving to translationally repress Mad expression ( Harris et al., 2011 ). Notably, inappropriate expression of Brat within GSCs results in a stem cell loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1509–1521.
Published: 15 April 2012
... of translational controls. This important role for translation is consistent with its general prominence in regulating gene expression in the C. elegans germ line ( Merritt et al., 2008 ). The comparison of PUF functions in different species thus provides an opportunity to study regulatory evolution...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 689–698.
Published: 15 February 2009
...Solenn Patalano; Marija Mihailovich; Yaiza Belacortu; Nuria Paricio; Fátima Gebauer Dosage compensation in Drosophila melanogaster involves the assembly of the MSL-2-containing dosage compensation complex (DCC) on the single X chromosome of male flies. Translational repression of msl-2 mRNA blocks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1547–1557.
Published: 15 April 2008
...Charles R. Tessier; Kendal Broadie Fragile X Syndrome (FraX) is a broad-spectrum neurological disorder with symptoms ranging from hyperexcitability to mental retardation and autism. Loss of the fragile X mental retardation 1 ( fmr1 ) gene product,the mRNA-binding translational regulator FMRP...
Journal Articles
Journal: Development
Development (2007) 134 (9): 1767–1777.
Published: 1 May 2007
... translation. The molecular basis of how the translation of mRNAs encoding guidance proteins could be closely tied to the pace of cytoskeletal assembly is poorly understood. Previous studies have shown that the F-actin-microtubule crosslinker Short stop (Shot) is required for motor and sensory axon extension...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (17): 4167–4178.
Published: 1 September 2004
... events such as establishment of polarity. In response to a meiotic checkpoint, activated by a delay in DNA double-strand break (DSB) repair during oogenesis, Vas is post-translationally modified, and this corresponds to a downregulation in Grk protein accumulation( Ghabrial and Schüpbach,1999...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2717–2728.
Published: 15 June 2003
... of Hoxb4 expression is restricted by regulating transcript stability in the paraxial mesoderm and by selective translation and/or degradation of protein in the neural tube. Moreover, the absence of Hoxb4 3′-untranslated sequences from transgene transcripts leads to inappropriate expression of some Hoxb4...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2623–2632.
Published: 15 June 2003
...Veronica A. Marin; Thomas C. Evans In C. elegans , the Notch receptor GLP-1 is localized within the germline and early embryo by translational control of glp-1 mRNA. RNA elements in the glp-1 3′untranslated region (3′ UTR) are necessary for repression of glp-1 translation in germ cells...
Journal Articles
Journal: Development
Development (2003) 130 (5): 835–843.
Published: 1 March 2003
..., however, it appears that the translational status of a regulated transcript is determined by the length of its poly(A) tail, and the switch from a silenced to a translationally active state is controlled by cytoplasmic polyadenylation (reviewed by Richter, 1999 ). Accordingly,an increase in translation...
Journal Articles
Journal: Development
Development (2002) 129 (1): 197–209.
Published: 1 January 2002
... ( Bouvet and Wolffe, 1994 ). MSY2 and MSY4 exist in an mRNP complex in mouse spermatocytes, and both proteins bind sequences within the 3′ UTR of Prm1 , a translationally repressed mRNA ( Davies et al., 2000 ). Based on the involvement of vertebrate Y-box proteins in translational regulation of stored...
Journal Articles
Journal: Development
Development (2001) 128 (14): 2823–2832.
Published: 15 July 2001
... is translationally repressed by Bruno (Bru; Aret – FlyBase) protein ( Kim-Ha et al., 1995 ; Webster et al., 1997 ). Additional factors, including Bicaudal C (BicC; Saffman et al., 1998 ), Apontic ( Lie and Macdonald, 1999 ) and possibly a factor named p50 ( Gunkel et al., 1998 ) also contribute to repression...
Journal Articles
Journal: Development
Development (1986) 94 (1): 207–220.
Published: 1 June 1986
.... 9, 221-230. STANDART, N. M., BRAY, S. J., GEORGE, E. L., HUNT, T. & RUDERMAN, J. V. (1985). The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal mRNAs in clam and sea urchin eggs. /. Cell Biol. 100, 1968-1976. STERN, S., RAYYIS...