... , K. A. , Kurial , S. N. T. , Hsu , B. Y. , Cast , A. E. , Donnelly , B. , Karns , R. A. , Chen , F. , Rezvani , M. , Luu , H. Y. et al. ( 2018 ). De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation . Nature 557 , 247...

... of pdx1 expression. We found four hit compounds and validated their efficacy at different stages of pancreas development. Notably, valproic acid treatment increased pancreatic endoderm formation, while inhibition of TGFβ signaling led to α-cell to β-cell transdifferentiation. HC toxin, another HDAC...

... of a root can morph in the span of a couple of cell division cycles into those of a shoot, and back, through transdifferentiation. In Arabidopsis , organogenesis can be induced in explants prepared from root or hypocotyl ( Atta et al., 2009 ; Che et al., 2006 ; Gordon et al., 2007 ; Valvekens et al...

... and the transdifferentiation of chondrocytes into osteoblasts. Rankl Tnfsf11 Tnfrsf11b Beta-catenin Chondrocyte-derived osteoblasts Trabecular bone Transdifferentiation Mouse Severe loss of trabecular bone leads to osteopenia/osteoporosis, while a gain in trabecular bone mass is termed osteopetrosis...

... direct conversion can shed light on unsolved questions in developmental biology. Conversion Direct reprogramming Neurogenesis Neuron Neuronal subtype Transdifferentiation Transcription factor During development, specific cell fates are programmed by extrinsic and intrinsic cues...

... to transcriptional activation in groups of prosensory cells, and that highly conserved sites for Hes/Hey repressor binding in the Atoh1 promoter are needed to select the hair cell and supporting cell fate. During perinatal supporting cell transdifferentiation, which is a model of hair cell regeneration, we show...

... and transdifferentiation, among other topics. In this meeting, translational research on stem cells for disease modeling and therapy was also presented. This Meeting Review describes key themes and selected findings, providing a timely update on this fast-moving area of research. References Bar-Nur , O...

...Lihua Ye; Morgan A. Robertson; Daniel Hesselson; Didier Y. R. Stainier; Ryan M. Anderson The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery...

... be harnessed to promote maturation of neurons obtained by transdifferentiation of human cells in vitro . * These authors contributed equally to this work ‡ Author for correspondence ( ap113@cam.ac.uk ) Competing interests The authors declare no competing financial interests. 22 11...

... molecular markers parallels loss of markers for the original differentiated pharynx state; hence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferentiation process. Based on high-resolution morphological characteristics, the transdifferentiated cells become...

... by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation. * Author for correspondence ( rph32@cam.ac.uk ) Competing interests statement The authors declare...

... maintenance and reprogramming during normal development, regeneration and oncogenic transformation. Retinal development Dedifferentiation Pupal eye Transdifferentiation Pigment cell Drosophila Terminal differentiation involves a complex and coordinated sequence of events through...

... contributed equally to this work † Author for correspondence ( sophie@igbmc.fr ) Competing interests statement The authors declare no competing financial interests. 31 1 2011 © 2011. 2011 Cellular reprogramming Transdifferentiation Collier/Olf1/Ebf C. elegans Rectum...

... that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa . Sodium...

...-associated insulin + cells. We found that hyperplastic ductal cells arose largely from acinar cells that changed their cell fate, or transdifferentiated, into ductal cells. However, insulin + cells adjacent to acinar-derived ductal cells arose from pre-existing insulin + cells, suggesting that islet...

... in epithelial character is associated with the appearance of nestin-positive transitional cells. Lineage tracing involving Cre/lox-mediated genetic cell labeling reveals that acinar-to-ductal metaplasia represents a true transdifferentiation event, mediated by initial dedifferentiation of mature exocrine cells...

... at the cellular level. Retina regeneration can occur in two distinct manners. The first is via transdifferentiation, which is induced by members of the Fibroblast growth factor (Fgf) family. The second type of retinal regeneration occurs from the anterior margin of the eye, near the ciliary body (CB) and ciliary...

... induced cell proliferation, alveolar hyperplasia and transdifferentiation of mammary epithelial cells into squamous epithelial cells. Consequently, all mutant mice developed squamous cell carcinoma and/or mammary abscesses between 5 and 16 months of age. We demonstrated that absence of Smad4 resulted in β...

... Transdifferentiation Organ development comprises a cascade of fate decisions, typically starting with a broad regional specification, followed by increasingly elaborate differentiation. The Drosophila imaginal disc provides a useful system in which to address these processes; we focus on the regional...

..., C. A. B. ( 1992 ). Cutured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development 115 , 587 -593. Robles, A. I. and Conti, C. J. ( 1995 ). Early overexpression of cyclin D1 in mouse skin carcinogenesis. Carcinogenesis 16...