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Keywords: Transdifferentiation
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Journal Articles
Journal: Development
Development (2021) 148 (3): dev197392.
Published: 5 February 2021
... the conversion. Adult liver, like lung, lacks dedicated stem cells. Stacey Huppert discussed how hepatocytes transdifferentiate to regenerate cholangiocytes if bile ducts are lost. Mice with altered Notch signaling due to deletion of RbpJ and Hnf6 display extreme intrahepatic bile duct paucity ( Sparks...
Journal Articles
Journal: Development
Development (2019) 146 (14): dev172569.
Published: 24 July 2019
... of pdx1 expression. We found four hit compounds and validated their efficacy at different stages of pancreas development. Notably, valproic acid treatment increased pancreatic endoderm formation, while inhibition of TGFβ signaling led to α-cell to β-cell transdifferentiation. HC toxin, another HDAC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1187–1200.
Published: 1 April 2017
... of a root can morph in the span of a couple of cell division cycles into those of a shoot, and back, through transdifferentiation. * These authors are co-first authors ‡ These authors are co-senior authors § Authors for correspondence ( pierre.hilson@inra.fr ; marco.da-costa@inra.fr...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3826–3838.
Published: 15 October 2016
.... Acad. Sci. USA   97 , 4052 - 4057 . 10.1073/pnas.060037197 Zhou , X. , von der Mark , K. , Henry , S. , Norton , W. , Adams , H. and de Crombrugghe , B. ( 2014 ). Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2494–2510.
Published: 15 July 2016
... , 905 - 981 . 10.1152/physrev.00041.2009 Zuryn , S. , Ahier , A. , Portoso , M. , White , E. R. , Morin , M.-C. , Margueron , R. and Jarriault , S. ( 2014 ). Sequential histone-modifying activities determine the robustness of transdifferentiation . Science   345...
Journal Articles
Journal: Development
Development (2016) 143 (5): 841–850.
Published: 1 March 2016
... to transcriptional activation in groups of prosensory cells, and that highly conserved sites for Hes/Hey repressor binding in the Atoh1 promoter are needed to select the hair cell and supporting cell fate. During perinatal supporting cell transdifferentiation, which is a model of hair cell regeneration, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2549–2553.
Published: 1 August 2015
... and transdifferentiation, among other topics. In this meeting, translational research on stem cells for disease modeling and therapy was also presented. This Meeting Review describes key themes and selected findings, providing a timely update on this fast-moving area of research. * Author for correspondence ( limd...
Journal Articles
Journal: Development
Development (2015) 142 (8): 1407–1417.
Published: 15 April 2015
...Lihua Ye; Morgan A. Robertson; Daniel Hesselson; Didier Y. R. Stainier; Ryan M. Anderson The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2216–2224.
Published: 1 June 2014
... be harnessed to promote maturation of neurons obtained by transdifferentiation of human cells in vitro . * These authors contributed equally to this work ‡ Author for correspondence ( ap113@cam.ac.uk ) Competing interests The authors declare no competing financial interests. 22 11...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4844–4849.
Published: 15 December 2013
... molecular markers parallels loss of markers for the original differentiated pharynx state; hence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferentiation process. Based on high-resolution morphological characteristics, the transdifferentiated cells become...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (12): 2468–2471.
Published: 15 June 2013
... by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation. * Author for correspondence ( rph32@cam.ac.uk ) Competing interests statement The authors declare...
Journal Articles
Journal: Development
Development (2013) 140 (1): 176–184.
Published: 1 January 2013
... 2012 © 2013. Published by The Company of Biologists Ltd Retinal development Dedifferentiation Pupal eye Transdifferentiation Pigment cell Drosophila Terminal differentiation involves a complex and coordinated sequence of events through which newly specified cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1483–1492.
Published: 15 April 2011
... and genetic analyses to probe the mechanisms underlying transdifferentiation. * These authors contributed equally to this work † Author for correspondence ( sophie@igbmc.fr ) Competing interests statement The authors declare no competing financial interests. 31 1 2011 ©...
Journal Articles
Journal: Development
Development (2010) 137 (18): 3047–3056.
Published: 15 September 2010
... that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa . Sodium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2289–2296.
Published: 15 July 2010
...-associated insulin + cells. We found that hyperplastic ductal cells arose largely from acinar cells that changed their cell fate, or transdifferentiated, into ductal cells. However, insulin + cells adjacent to acinar-derived ductal cells arose from pre-existing insulin + cells, suggesting that islet...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3767–3776.
Published: 15 August 2005
... in epithelial character is associated with the appearance of nestin-positive transitional cells. Lineage tracing involving Cre/lox-mediated genetic cell labeling reveals that acinar-to-ductal metaplasia represents a true transdifferentiation event, mediated by initial dedifferentiation of mature exocrine cells...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (18): 4607–4621.
Published: 15 September 2004
... at the cellular level. Retina regeneration can occur in two distinct manners. The first is via transdifferentiation, which is induced by members of the Fibroblast growth factor (Fgf) family. The second type of retinal regeneration occurs from the anterior margin of the eye, near the ciliary body (CB) and ciliary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (24): 6143–6153.
Published: 15 December 2003
... induced cell proliferation, alveolar hyperplasia and transdifferentiation of mammary epithelial cells into squamous epithelial cells. Consequently, all mutant mice developed squamous cell carcinoma and/or mammary abscesses between 5 and 16 months of age. We demonstrated that absence of Smad4 resulted in β...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5313–5322.
Published: 1 December 2002
... excess BrdU incorporation posterior to the furrow in axin - clones( Fig. 2B ). * Author for correspondence (e-mail: mf1@mrc-lmb.cam.ac.uk ) 15 8 2002 ©2002. 2002 Drosophila Wingless Axin Eyes absent Sine oculis Dachshund Eye Transdetermination Transdifferentiation...
Journal Articles
Journal: Development
Development (2002) 129 (1): 95–109.
Published: 1 January 2002
... ) 22 10 2001 © 2002. 2002 β-catenin Lef1 Epidermis Transdifferentiation Hair follicles Tumours Mouse The Wnt signalling pathway controls many morphogenetic events during embryonic development ( Miller and Moon, 1996 ). Secreted Wnt proteins bind to transmembrane receptors...