.... Summary: Changes in transcriptional dynamics of even-skipped upon halving Krüppel dosage reveal how the combination of direct transcription factor (TF)-DNA and indirect TF-TF interactions shape proper patterning. Transcriptional regulation Live imaging Drosophila Even-skipped Krüppel...

... Even-skipped Transcriptional regulation Zelda Drosophila National Institutes of Health RO1 GM 51946 Hamilton College http://dx.doi.org/10.13039/100009252 The Drosophila zinc-finger protein Zelda (Zld) is a key regulator of hundreds of zygotic genes during...

... the response to retinoic acid. Hox genes Transcriptional regulation Shared enhancers Nascent transcription smFISH Retinoic acid signaling Retinoic acid response elements RAREs Neural tube Mouse development Stowers Institute for Medical Research http://dx.doi.org/10.13039/100007795...

... regulators. Alveolar development Transcriptional regulation Cell proliferation Lung mesenchyme Lipofibroblast Myofibroblast National Institutes of Health HL126703 UL1TR001442 HL086324 National Heart, Lung, and Blood Institute http://dx.doi.org/10.13039/100000050...

... of the complex system of tissue-specific WNT/β-catenin target genes, together with other non-DNA-binding transcriptional regulators that act downstream of ontogenetically fundamental signaling cascades. Human embryonic kidney 293T cells (HEK293T) were obtained by previous work ( Doumpas et al., 2019...

... proliferation and patterning is identified involving protein-protein interactions. Dental epithelial stem cells Pitx2 Shh Signaling centers Sox2 Transcriptional regulation Stem cell niche Craniofacial/tooth development Irx1 Enamel knot University of Iowa 10.13039/100008893 EB025873...

... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...

... the role of MLL proteins and H3K4me1 in ESC transcriptional regulation. Of particular interest would be to determine the extent to which MLL function is required for maintenance of enhancer activity as opposed to de novo activation during cell state transitions. MLL proteins also act in concert...

... border of the expression domain of Tbx6 protein. During somite segmentation, the expression domain of Tbx6 is regressed by Ripply-meditated degradation of Tbx6 protein. Although the expression of zebrafish tbx6 remains restricted to the PSM, the transcriptional regulation of tbx6 remains poorly...

.... ( 2014 ). BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51 . J. Cell Sci.   128 , 317 - 330 . 10.1242/jcs.159103 Raab , J. R. , Resnick , S. and Magnuson , T. ( 2015 ). Genome-wide transcriptional regulation mediated...

... of the STM gene regulatory network (GRN) are largely unknown. Here, we show that transcriptional regulators are overrepresented among STM-regulated genes and, using these as GRN components in Bayesian network analysis, we infer STM GRN associations and reveal regulatory relationships between STM and factors...

... Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677 Seventh Framework Programme 10.13039/100011102 FP7/2009 BOLD 238821 Centre National de la Recherche...

... will be the lens through which we can examine the mechanistic underpinnings of quantitative transcriptional features and thus determine the raison d’être of gene regulatory pathways. Box 1. Definitions of features of transcriptional regulation Transcriptional precision. High transcriptional precision...

...., 1993 ; Sturtevant and Bier, 1995 ; de Celis, 2003 ). Optix Spalt Vein patterning Drosophila wing Transcriptional regulation Summary: The position of vein L2 in the Drosophila wing is permanently and dynamically established through cross-interactions of Aristaless, Spalt mayor...

... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...

..., metabolic processes and zygote morphology, identifying Setd1b as a key regulator of oocyte development. Histone methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Deutsche Forschungsgemeinschaft 10.13039/501100001659 KR2154/3-1 STE903/4-1...

... transgenic animal lines. DamID Transcription factor Transcriptional regulation Chromatin profiling Epigenetics Deutsche Forschungsgemeinschaft 10.13039/501100001659 CRC 873 European Research Council 10.13039/501100000781 GA 294354-ManISteC Animal development...

... European Molecular Biology Organization 10.13039/100004410 Histone methylation Meiosis Mitosis Pre-implantation development Transcriptional regulation Highlighted article: The H3K9 methyltransferase Setdb1 is required during mouse oogenesis to control gene expression, restrain...

... repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse Sonic hedgehog (Shh) signaling is crucial for the specification of ventral neural progenitor types that give rise to molecularly...