... the response to retinoic acid. Hox genes Transcriptional regulation Shared enhancers Nascent transcription smFISH Retinoic acid signaling Retinoic acid response elements RAREs Neural tube Mouse development Stowers Institute for Medical Research http://dx.doi.org/10.13039/100007795...

.... ( 2021 ). FGF10 and lipofibroblasts in lung homeostasis and disease: insights gained from the adipocytes . Front. Cell Dev. Biol. 9 , 645400 . 10.3389/fcell.2021.645400 Majello , B. , De Luca , P. and Lania , L. ( 1997 ). Sp3 is a bifunctional transcription regulator...

... of the complex system of tissue-specific WNT/β-catenin target genes, together with other non-DNA-binding transcriptional regulators that act downstream of ontogenetically fundamental signaling cascades. References Amemiya , H. M. , Kundaje , A. and Boyle , A. P. ( 2019 ). The ENCODE...

... regeneration Cardiomyocyte proliferation Metabolism Transcriptional regulation Wnt/β-catenin Highlighted Article: β-Catenin is repurposed from pro-proliferative to protective functions in cardiomyocytes during postnatal heart development. © 2020. Published by The Company of Biologists Ltd...

... proliferation and patterning is identified involving protein-protein interactions. Dental epithelial stem cells Pitx2 Shh Signaling centers Sox2 Transcriptional regulation Stem cell niche Craniofacial/tooth development Irx1 Enamel knot Pituitary homeobox 2 ( Pitx2 ), is a crucial...

... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...

...@ucsf.edu ) Competing interests The authors declare no competing or financial interests. © 2019. Published by The Company of Biologists Ltd 2019 Summary: In this Review, we discuss emerging concepts of the various levels of epigenetic control of transcriptional regulation...

... border of the expression domain of Tbx6 protein. During somite segmentation, the expression domain of Tbx6 is regressed by Ripply-meditated degradation of Tbx6 protein. Although the expression of zebrafish tbx6 remains restricted to the PSM, the transcriptional regulation of tbx6 remains poorly...

...://www.biologists.com/user-licence-1-1/ Summary: Epigenetic studies of BRG1 reveal for the first time that SWI/SNF and PRC1 cooperate during gametogenesis to regulate transcription. SWI/SNF chromatin remodeling BRG1 Transcriptional regulation SCML2 Spermatogenesis is a developmental cascade...

... of the STM gene regulatory network (GRN) are largely unknown. Here, we show that transcriptional regulators are overrepresented among STM-regulated genes and, using these as GRN components in Bayesian network analysis, we infer STM GRN associations and reveal regulatory relationships between STM and factors...

... ). FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgamma-induced urothelial cytodifferentiation . Cell Death Differ.   1 , 103 - 114 . 10.1038/cdd.2008.116 Verdeguer , F. , Le Corre , S. , Fischer , E. , Callens , C. , Garbay , S. , Doyen , A. , Igarashi...

.... Precision Accuracy Drosophila development Embryo Transcriptional regulation Modeling In animals, changes in gene regulation are associated with phenotypic changes within and between species ( Chen and Rajewsky, 2007 ; Gompel et al., 2005 ; McGregor et al., 2007 ; Simpson, 2007 ; Wittkopp...

...’ stage terminates with the establishment of longitudinal domains of Epidermal growth factor receptor (EGFR) signalling activity ( Sturtevant et al., 1993 ; Sturtevant and Bier, 1995 ; de Celis, 2003 ). Optix Spalt Vein patterning Drosophila wing Transcriptional regulation Summary...

...-establishment of DNA methylation ( Stewart et al., 2015 ; Dahl et al., 2016 ; Liu et al., 2016 ; Zhang et al., 2016 ). Histone methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Highlighted article: Oocyte-specific knockout of Setd1b in mouse disrupts...

... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...

... specificity and sensitivity in determining genome-wide protein-DNA interactions in transient or stable transgenic animal lines. DamID Transcription factor Transcriptional regulation Chromatin profiling Epigenetics Animal development is the result of an exquisite orchestration of changes...

... early embryonic development (developmental competence) in absence of transcription ( Hirao et al., 1993 ; Inoue et al., 2008 ; Wickramasinghe et al., 1991 ; Zuccotti et al., 2011 , 2002 ). Histone methylation Meiosis Mitosis Pre-implantation development Transcriptional regulation...

... by The Company of Biologists Ltd 2015 Summary: Unbiased functional genomics approaches reveal that Nkx2.2, Nkx6.1 and Olig2 directly repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse...

... Summary: Meiotic chromosomal regions that fail to synapse elicit meiotic silencing of unsynapsed chromatin (MSUC), which shows similarities to the DNA damage response to replication stress in somatic cells. Meiosis Spermatogenesis Transcriptional regulation CHEK1 Mouse Transcription...

... , and demonstrate that decreased Pdgfrb dosage in conditional Pbx1 mutants substantially rescues vascular patterning defects and neonatal survival. These findings identify, for the first time, an in vivo transcriptional regulator of PDGFRβ, and reveal a previously unappreciated role for VMCs in systems-level...