... in cardiomyocytes during postnatal heart development. Cardiac regeneration Cardiomyocyte proliferation Metabolism Transcriptional regulation Wnt/β-catenin To understand how β-catenin facilitated cardioprotection rather than regeneration in the adult heart, RNA-seq was performed on cardiomyocytes...

... controlling stem cell proliferation and patterning is identified involving protein-protein interactions. Dental epithelial stem cells Pitx2 Shh Signaling centers Sox2 Transcriptional regulation Stem cell niche Craniofacial/tooth development Irx1 Enamel knot Pituitary homeobox 2 ( Pitx2...

... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...

... and differentiation, and which factors are involved? Besides more standardized culture conditions, several recent technological advances have proven suitable to address the mechanisms underlying the dynamic interplay of chromatin structure and transcriptional regulation. These include implementations of single...

... border of the expression domain of Tbx6 protein. During somite segmentation, the expression domain of Tbx6 is regressed by Ripply-meditated degradation of Tbx6 protein. Although the expression of zebrafish tbx6 remains restricted to the PSM, the transcriptional regulation of tbx6 remains poorly...

... coordinate nucleosome occupancy at promoters to achieve transcriptional regulation ( Tolstorukov et al., 2013 ). The transcriptional outcome is often dictated by the subunit composition of the complex, which in turn can influence its genome-wide association and interactions with other gene regulators...

... of the STM gene regulatory network (GRN) are largely unknown. Here, we show that transcriptional regulators are overrepresented among STM-regulated genes and, using these as GRN components in Bayesian network analysis, we infer STM GRN associations and reveal regulatory relationships between STM and factors...

... cell organization and for further differentiation of the collecting duct system. Kidney Branching morphogenesis Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Mitotic GFP + cells are of circular shape with bright boundaries and dark centers; they were...

.... Precision Accuracy Drosophila development Embryo Transcriptional regulation Modeling Technological advances have provided new tools to further dissect the mechanisms that contribute to precise and accurate transcription. Measuring the timing, location and level of gene expression across...

... Transcriptional regulation Pattern formation is a developmental operation that generates bi-dimensional arrays of cells with particular differentiation characteristics ( Martin et al., 2016 ). Classical examples of pattern formation processes that have been subject to intensive genetic and developmental...

... methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Resetting the epigenome during germ cell development establishes the tabula rasa essential for early development. In the mouse, primordial germ cells originate from the base of the allantois and migrate through...

... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...

... in transient or stable transgenic animal lines. DamID Transcription factor Transcriptional regulation Chromatin profiling Epigenetics E. coli Dam (eDam) displays specific methylation activity on its cognate GATC but also minor unspecific methylation on near-cognate sequences ( Horton...

... expression of endogenous retroviruses and enable successful progression through meiosis and mitosis. Histone methylation Meiosis Mitosis Pre-implantation development Transcriptional regulation Mouse female germ cells enter meiosis during fetal development and arrest at the dictyate stage...

... repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse Sonic hedgehog (Shh) signaling is crucial for the specification of ventral neural progenitor types that give rise to molecularly...

... Summary: Meiotic chromosomal regions that fail to synapse elicit meiotic silencing of unsynapsed chromatin (MSUC), which shows similarities to the DNA damage response to replication stress in somatic cells. Meiosis Spermatogenesis Transcriptional regulation CHEK1 Mouse Transcription...

... , and demonstrate that decreased Pdgfrb dosage in conditional Pbx1 mutants substantially rescues vascular patterning defects and neonatal survival. These findings identify, for the first time, an in vivo transcriptional regulator of PDGFRβ, and reveal a previously unappreciated role for VMCs in systems-level...

...@neurosurg.ucsf.edu ) Competing interests The author declares no competing or financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Summary: A recent Keystone Symposium highlighted major advances in our comprehension of the epigenetic and transcriptional regulation of stem...

.... Our in vitro data make this latter scenario less likely, as upregulation of Hoxa9 is recapitulated in vitro when geminin is depleted from K562 cells. In vitro experiments have, in addition, provided mechanistic insight into the pathway leading to transcriptional regulation by geminin. Hox...

... signaling pathways is currently not clearly understood. Wnt signaling R-spondins Cardiac development Transcriptional regulation Angiogenesis Nkx2-5 Rspo3 © 2014. Published by The Company of Biologists Ltd 2014 5 9 2013 28 5 2014 Competing interests The authors...