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Keywords: Transcription factors
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Journal Articles
Journal: Development
Development (2021) 148 (17): dev199814.
Published: 03 September 2021
...Stephanie A. Campbell; Tabea L. Stephan; Jeremy Lotto; Rebecca Cullum; Sibyl Drissler; Pamela A. Hoodless ABSTRACT Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev191544.
Published: 23 November 2020
... to malignant tumours after allografting to adult hosts. We combined transcriptomic data from these hyperplasias with chromatin occupancy data for Dpn, a Hes transcription factor, to identify genes regulated by Hes factors in this process. We show that the Notch/Hes axis represses a cohort of transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev161430.
Published: 05 October 2020
...Albert Tsai; Rafael Galupa; Justin Crocker ABSTRACT Developmental enhancers drive gene expression in specific cell types during animal development. They integrate signals from many different sources mediated through the binding of transcription factors, producing specific responses in gene...
Journal Articles
Journal: Development
Development (2019) 146 (6): dev167080.
Published: 19 March 2019
... Skeletal muscle Transcription factors Epigenetics Cell signaling Differentiation Skeletal muscle owes its considerable regenerative capacity to a population of resident muscle stem cells called satellite cells ( Lepper et al., 2011 ; McCarthy et al., 2011 ; Murphy et al., 2011 ; Sambasivan...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev168179.
Published: 25 January 2019
...Dimitrios K. Papadopoulos; Kassiani Skouloudaki; Ylva Engström; Lars Terenius; Rudolf Rigler; Christoph Zechner; Vladana Vukojević; Pavel Tomancak; Allon Klein; Barbara Treutlein ABSTRACT The variability in transcription factor concentration among cells is an important developmental determinant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev162990.
Published: 11 October 2018
...-loop-helix family of transcription factors that are co-expressed in the erythroid lineage. Previous studies have suggested that Scl is essential for primitive erythropoiesis. However, analysis of single-cell RNA-seq data of early embryos showed that primitive erythroid cells express both Scl and Lyl1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev150433.
Published: 23 July 2018
... to study the origin of human primordial germ cells, prompting further consideration of the somatic cell fate decisions that occur during early human development. Primordial germ cells Gastrulation Epiblast Human development Epigenetic resetting Transcription factors Signalling Amnion...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (13): dev161646.
Published: 10 July 2018
..., yet plastic, mature organ. Over the past couple of decades, studies have revealed that hormonal signals, transcription factors and miRNAs play major roles during leaf development, and more recent findings have highlighted the contribution of mechanical signals to leaf growth. In this Review, we...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev161208.
Published: 29 March 2018
... of their formation is still limited. To gain insight into the molecular mechanisms of connective tissue specification, we selected five zinc-finger transcription factors – OSR1, OSR2, EGR1, KLF2 and KLF4 – based on their expression patterns and/or known involvement in connective tissue subtype differentiation. RNA...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (5): dev158105.
Published: 01 March 2018
..., development of the Arabidopsis gynoecium is tightly controlled by distribution and synthesis of the plant hormone auxin. The functions of several transcription factors (TFs) have been linked with auxin dynamics during gynoecium development; yet how their activities are coordinated is not known. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3867–3878.
Published: 01 November 2017
... are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3633–3645.
Published: 15 October 2017
... of binding their genomic targets during mitosis. These so-called ‘mitotic bookmarking factors’ encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development...
Journal Articles
Journal: Development
Development (2016) 143 (24): 4558–4570.
Published: 15 December 2016
...Maria L. Golson; Klaus H. Kaestner Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human...
Journal Articles
Journal: Development
Development (2016) 143 (20): 3650–3660.
Published: 15 October 2016
...Paulina Anna Latos; Myriam Hemberger Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have shown how signalling cascades integrate with transcription factor circuits...
Journal Articles
Journal: Development
Development (2015) 142 (16): 2810–2821.
Published: 15 August 2015
...Israt Jahan; Ning Pan; Jennifer Kersigo; Bernd Fritzsch Atoh1 , a basic helix-loop-helix (bHLH) transcription factor (TF), is essential for the differentiation of hair cells (HCs), mechanotransducers that convert sound into auditory signals in the mammalian organ of Corti (OC). Previous work...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2094–2108.
Published: 15 June 2015
... ; Rountree et al., 2007 ; Suzuki et al., 2008 ), CD24 ( Qiu et al., 2011 ) and by the transcription factors SOX9 ( Dorrell et al., 2011 ; Furuyama et al., 2011 ), FOXL1 ( Shin et al., 2011 ) and LGR5 ( Huch et al., 2013 ). A few studies have shown some contribution of oval cells to the hepatocyte lineage...
Journal Articles
Journal: Development
Development (2015) 142 (12): 2184–2193.
Published: 15 June 2015
... metabolism and cell growth. Silencing of these genes impaired early glia proliferation and subsequent differentiation. Dref controls proliferation via activation of the Pdm3 transcription factor, whereas glial differentiation is regulated via Dref and the homeodomain protein Cut. Cut expression is controlled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2109–2120.
Published: 15 June 2015
... neuronal replacement throughout life. Neurogenesis Patterning Specification Subventricular zone Transcription factors Even though all the NSCs contained in the V-SVZ are geared towards the life-long replenishment of olfactory neurons, NSCs across the ventricular system differ in many...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (2): 242–257.
Published: 15 January 2015
... no competing financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Summary : The current status of the neural crest gene regulatory network is reviewed, emphasizing the connections between transcription factors, signalling molecules and epigenetic modifiers. Gene...
Journal Articles
Journal: Development
Development (2014) 141 (24): 4667–4680.
Published: 15 December 2014
...Celine Santiago; Greg J. Bashaw Transcription factors establish the tremendous diversity of cell types in the nervous system by regulating the expression of genes that give a cell its morphological and functional properties. Although many studies have identified requirements for specific...