... that increases ploidy and is rate limiting for the expression of ecdysone biosynthetic genes. Molecularly, we show that KDM5 activates the expression of the receptor tyrosine kinase torso , which then promotes polyploidization and growth through activation of the MAPK signaling pathway. Taken together, our...

...Fabian Pridöhl; Matthias Weißkopf; Nikolaus Koniszewski; Andreas Sulzmaier; Steffen Uebe; Arif B. Ekici; Michael Schoppmeier Terminal regions of the Drosophila embryo are patterned by the localized activation of the Torso-RTK pathway, which promotes the downregulation of Capicua. In the short-germ...

... of the embryo through the uneven activation of the Torso (Tor) receptor in its membrane. This process relies on the restricted expression of the gene torso-like ( tsl ) in subpopulations of follicle cells during oogenesis and its protein accumulation at both poles of the eggshell, but it is not known how...

... for signaling by wild-type and mutant forms of the RTK Torso (Tor) using a genetic approach in Drosophila . Our results indicate that the JAK/STAT pathway plays little or no role in signaling by wild-type Tor. In contrast, we find that STAT, encoded by marelle ( mrl; DStat92E ), is essential for the gain...

...Andreu Casali; Jordi Casanova ABSTRACT Regulated activation of receptor tyrosine kinases depends on both the presence of the receptors at the cell surface and on the availability of their ligands. In Drosophila , the torso tyrosine kinase receptor is distributed along the surface of the embryo...

... genes is mediated by the local activation of the Torso receptor tyrosine kinase (Tor). At the anterior, terminal gap genes are also activated by the Tor pathway but Bcd contributes to their activation. Here we present evidence that Tor and Bcd act independently on common target genes in an additive...

...Florence Janody; Rachel Sturny; Françoise Catala; Claude Desplan; Nathalie Dostatni ABSTRACT The Torso signal transduction pathway exhibits two opposite effects on the activity of the Bicoid (Bcd) morphogen: (i) Bcd function is repressed by Torso (Tor) at the anterior pole of the embryo leading...

...Marc Furriols; Frank Sprenger; Jordi Casanova ABSTRACT Activation of receptor tyrosine kinases triggers many developmental decisions, yet we do not understand how activation of a single receptor can be transduced into different cell responses. The torso pathway in Drosophila provides a model...

... that fusion of the pelle catalytic domain to the transmembrane receptor torso is sufficient to induce ventral fates; this activity is independent of Toll or tube. Lastly, we find that fusion of the tube protein to torso also induces ventral fates, but only in the presence of functional pelle. We propose...

...Fernando J. Diaz-Benjumea; Ernst Hafen ABSTRACT In Drosophila , Drk, an SH2 adaptor protein, Sos, a putative activator of Ras1, Ras1, raf and rolled/MAP kinase have been shown to be required for signalling from the sevenless and the torso receptor tyrosine kinase. From these studies, it was unclear...