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Keywords: Tooth
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
...Isabel Mogollón; Jacqueline E. Moustakas-Verho; Minna Niittykoski; Laura Ahtiainen ABSTRACT Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian molar tooth, reiterative signaling in specialized centers called enamel knots (EKs) determines tooth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2824–2836.
Published: 01 August 2017
... signaling, we performed an array of genetic analyses in murine tooth development, where Lrp4 and Wise play important roles. We provide genetic evidence that Lrp4 mediates the Wnt inhibitory function of Wise and also modulates Wnt/β-catenin signaling independently of Wise. Chimeric receptor analyses raise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 374–384.
Published: 01 February 2017
...Jingyuan Li; Carolina Parada; Yang Chai ABSTRACT The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelial-mesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervations...
Journal Articles
Journal: Development
Development (2015) 142 (1): 128–139.
Published: 01 January 2015
...Guohua Yuan; Guobin Yang; Yuqian Zheng; Xiaojing Zhu; Zhi Chen; Zunyi Zhang; YiPing Chen BMP and Wnt signaling pathways play a crucial role in organogenesis, including tooth development. Despite extensive studies, the exact functions, as well as if and how these two pathways act coordinately...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2697–2702.
Published: 01 July 2013
...Irfan Saadi; Pragnya Das; Minglian Zhao; Lakshmi Raj; Intan Ruspita; Yan Xia; Virginia E. Papaioannou; Marianna Bei Bmp4 expression is tightly regulated during embryonic tooth development, with early expression in the dental epithelial placode leading to later expression in the dental mesenchyme...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
..., regulation and function of the jagged 2 ( Jag2 ) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth. Jag2 is expressed in epithelial cells that give rise to the enamel-producing ameloblasts from the earliest stages of tooth development. Tissue recombination experiments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (2): 323–334.
Published: 15 January 2005
...Päivi Kettunen; Sigbjørn Løes; Tomasz Furmanek; Karianne Fjeld; Inger Hals Kvinnsland; Oded Behar; Takeshi Yagi; Hajime Fujisawa; Seppo Vainio; Masahiko Taniguchi; Keijo Luukko During development, trigeminal nerve fibers navigate and establish their axonal projections to the developing tooth...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2257–2268.
Published: 15 May 2004
... and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4451–4460.
Published: 15 September 2003
... loop exists between ISL1 and BMP4 in distal epithelium. Ectopic expression of Islet1 in proximal epithelium produces a loss of Barx1 expression in the mesenchyme and resulted in inhibition of molar tooth development. Using epithelial/mesenchymal recombinations we show that at E10.5 Islet1 expression...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2027–2037.
Published: 15 May 2003
... pattern leads subsequently to a new form, during brain development changes in form and pattern reciprocally bring one another about in a morphodynamic fashion. Multiple lines of evidence indicate that tooth development employs morphodynamic mechanisms. Mammalian cheek teeth, in particular, possess...
Journal Articles
Journal: Development
Development (2003) 130 (6): 1049–1057.
Published: 15 March 2003
...Mark Tummers; Irma Thesleff The rodent incisor grows continuously throughout its lifetime. The epithelial stem cell niche is located at the apical end of the tooth and its progeny gives rise to the ameloblasts that form the hard enamel. Previously,mesenchymal FGF10 was shown to support the niche...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5323–5337.
Published: 01 December 2002
...Amel Gritli-Linde; Marianna Bei; Richard Maas; Xiaoyan M. Zhang; Anders Linde; Andrew P. McMahon Sonic hedgehog ( Shh ), a member of the mammalian Hedgehog(Hh) family, plays a key role during embryogenesis and organogenesis. Tooth development, odontogenesis, is governed by sequential and reciprocal...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4371–4386.
Published: 01 October 2002
... et al., 1995 ), although whether they are atavistic has been debated ( Smith and Schneider, 1998 ). Later expression of the Dlx genes in the ectomesenchyme and surface ectoderm ( Thomas et al., 1995 ; Zhao et al., 2000 ) contributes to tooth development. For example, Dlx1/Dlx2 double mutants lack...