...Isabel Mogollón; Jacqueline E. Moustakas-Verho; Minna Niittykoski; Laura Ahtiainen ABSTRACT Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian molar tooth, reiterative signaling in specialized centers called enamel knots (EKs) determines tooth...

... signaling, we performed an array of genetic analyses in murine tooth development, where Lrp4 and Wise play important roles. We provide genetic evidence that Lrp4 mediates the Wnt inhibitory function of Wise and also modulates Wnt/β-catenin signaling independently of Wise. Chimeric receptor analyses raise...

...Jingyuan Li; Carolina Parada; Yang Chai ABSTRACT The tooth root is an integral, functionally important part of our dentition. The formation of a functional root depends on epithelial-mesenchymal interactions and integration of the root with the jaw bone, blood supply and nerve innervations...

...Guohua Yuan; Guobin Yang; Yuqian Zheng; Xiaojing Zhu; Zhi Chen; Zunyi Zhang; YiPing Chen BMP and Wnt signaling pathways play a crucial role in organogenesis, including tooth development. Despite extensive studies, the exact functions, as well as if and how these two pathways act coordinately...

...Irfan Saadi; Pragnya Das; Minglian Zhao; Lakshmi Raj; Intan Ruspita; Yan Xia; Virginia E. Papaioannou; Marianna Bei Bmp4 expression is tightly regulated during embryonic tooth development, with early expression in the dental epithelial placode leading to later expression in the dental mesenchyme...

..., regulation and function of the jagged 2 ( Jag2 ) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth. Jag2 is expressed in epithelial cells that give rise to the enamel-producing ameloblasts from the earliest stages of tooth development. Tissue recombination experiments...

...Päivi Kettunen; Sigbjørn Løes; Tomasz Furmanek; Karianne Fjeld; Inger Hals Kvinnsland; Oded Behar; Takeshi Yagi; Hajime Fujisawa; Seppo Vainio; Masahiko Taniguchi; Keijo Luukko During development, trigeminal nerve fibers navigate and establish their axonal projections to the developing tooth...

... and its derivatives causes arrest of tooth morphogenesis and lack of external hair. The hair shaft and hair follicle inner root sheath (IRS) fail to differentiate, and expression of the known transcriptional regulators of follicular differentiation Msx1,Msx2, Foxn1 and Gata3 is markedly downregulated...

... loop exists between ISL1 and BMP4 in distal epithelium. Ectopic expression of Islet1 in proximal epithelium produces a loss of Barx1 expression in the mesenchyme and resulted in inhibition of molar tooth development. Using epithelial/mesenchymal recombinations we show that at E10.5 Islet1 expression...

... Morphostatic development Morphogenesis Tooth Brain Limb Evolution Genetic networks Evolution of metazoan organisms has produced, over hundreds of millions of years, both phenotypic complexity and the developmental mechanisms by which such complexity is generated. During development a single cell...

...Mark Tummers; Irma Thesleff The rodent incisor grows continuously throughout its lifetime. The epithelial stem cell niche is located at the apical end of the tooth and its progeny gives rise to the ameloblasts that form the hard enamel. Previously,mesenchymal FGF10 was shown to support the niche...

...Amel Gritli-Linde; Marianna Bei; Richard Maas; Xiaoyan M. Zhang; Anders Linde; Andrew P. McMahon Sonic hedgehog ( Shh ), a member of the mammalian Hedgehog(Hh) family, plays a key role during embryogenesis and organogenesis. Tooth development, odontogenesis, is governed by sequential and reciprocal...

... Neural tube Olfaction Placode Telencephalon Tooth Tricho-dento-osseous syndrome (TDO) Split hand/split foot malformation (SHFM) GABAergic Otic © 2002. 2002 5 7 2002 *Author for correspondence (e-mail: [email protected] ) The adult telencephalon contains neural...

... development, taking the tooth as our model system, and find that they are not expressed in adjacent cells as would have been expected. Teeth develop by a well recorded series of epithelial-mesenchymal interactions, similar to those in hair follicle and sweat gland development, the structures found...

...Marianna Bei; Klaus Kratochwil; Richard L. Maas ABSTRACT The development of many organs depends on sequential epithelial-mesenchymal interactions, and the developing tooth germ provides a powerful model for elucidating the nature of these inductive tissue interactions. In Msx1 -deficient mice...

...Zoë Hardcastle; Rong Mo; Chi-chung Hui; Paul T. Sharpe ABSTRACT The expression of genes involved in the Sonic Hedgehog signalling pathway, including Shh, Ptc, Smo, Gli1, Gli2 and Gli3 , were found to be expressed in temporal and spatial patterns during early murine tooth development, suggestive...

.... The Serrate-1 gene is expressed from embryonic day 7.5 (E7.5) and expression is often observed at sites of epithelial-mesenchymal interactions, including the developing tooth, where Serrate-1 is first (E11.5) expressed in all cells of the dental epithelium, but not in mesenchyme. A transient upregulation...

... nonneural organs where epithelial-mesenchymal interactions are involved. We show the following. (1) mRNA encoding tachykinin precursor proteins is expressed transiently in condensing mes-enchyme during the development of mouse tooth germ, mammary gland, limb bud, external auditory meatus and genital...

..., Nutley, New Jersey 07110, USA 28 09 1988 © 1989 by Company of Biologists 1989 proto-oncogene int -2 growth factors mouse development cerebellum retina tooth inner ear There is increasing evidence that growth factors and their receptors have important roles...