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Keywords: Tolloid
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Journal Articles
Journal: Development
Development (2006) 133 (20): 4035–4044.
Published: 15 October 2006
... mutant that shows strong defects in the neuromuscular connectivity pattern. In piranha mutant embryos, permanent defasciculation errors occur at specific choice points in all motor pathways. Positional cloning of piranha revealed point mutations in tolloid-related 1 ( tlr1 ), an evolutionarily conserved...
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (2): 413–424.
Published: 15 January 2004
...Lise Zakin; E. M. De Robertis Twisted gastrulation (Tsg) is a secreted protein that regulates Bmp signaling in the extracellular space through its direct interaction with Bmp/Dpp and Chordin (Chd)/Short gastrulation (Sog). The ternary complex of Tsg/Chd/Bmp is cleaved by the metalloprotease Tolloid...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4975–4988.
Published: 15 October 2003
... BMP4 Tolloid BMP signaling Xenopus CCN family Secreted signaling molecules are critical for coordinating cell fate specification and cell behavior. Bone morphogenetic proteins (BMPs) comprise the largest subgroup of the transforming growth factor beta (TGFβ)superfamily of secreted...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4047–4056.
Published: 1 September 2003
...Michael Oelgeschläger; Bruno Reversade; Juan Larraín; Shawn Little; Mary C. Mullins; E. M. De Robertis The determination of the vertebrate dorsoventral body axis is regulated in the extracellular space by a system of interacting secreted molecules consisting of BMP, Chordin, Tolloid and Twisted...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4439–4447.
Published: 15 November 2001
... ( Oelgeschläger et al., 2000 ; Ross et al., 2001 ; Chang et al., 2001 ). In Drosophila , Tsg changes the specificity of Tolloid cleavage causing the formation of a new fragment of the Chordin homolog Sog, called Supersog, which has been found both in embryo extracts and by in vitro digestion of Sog...
Journal Articles
Journal: Development
Development (1999) 126 (14): 3119–3130.
Published: 15 July 1999
... inhibitors of Bmps, such as Chordin, Noggin and Follistatin, are implicated in dorsal mesodermal and neural development. We investigated the role of Tolloid, a metalloprotease that can cleave Chordin and increase Bmp activity, in patterning the dorsoventral axis of the zebrafish embryo. Injection of tolloid...
Journal Articles
Journal: Development
Development (1994) 120 (4): 861–870.
Published: 1 April 1994
..., appears to play the central role in dorsal ectoderm formation, as mutations in this gene confer the most severe mutant phenotype of this group of genes. dpp’s activity is modulated by tolloid , which also has a role in the determination of dorsal cell fate. tolloid encodes a protein that contains...
Journal Articles
Journal Articles