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Keywords: Toll-like receptor
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Journal Articles

MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo

Laura F. Bennett, Melanie D. Mumau, Yan Li, Nancy A. Speck
Journal: Development
Development (2022) 149 (8): dev200025.
https://doi.org/10.1242/dev.200025
Published: 11 February 2022
... can be uncoupled. Mutations impairing MyD88-dependent toll-like receptor (TLR) signaling decreased the number of IAHC cells and LMPs, but increased the number of HSCs in the aorta-gonad-mesonephros region of mouse embryos. TLR4-deficient embryos generated normal numbers of HE cells, but IAHC cell...
View article titled, MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo
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Includes: Supplementary data
Journal Articles

Age-related changes in expression and function of Toll-like receptors in human skin

Nousheen Iram, Michael Mildner, Marion Prior, Peter Petzelbauer, Christian Fiala, Stefan Hacker, Alice Schöppl, Erwin Tschachler, Adelheid Elbe-Bürger
Journal: Development
Development (2012) 139 (22): 4210–4219.
https://doi.org/10.1242/dev.083477
Published: 15 November 2012
...Nousheen Iram; Michael Mildner; Marion Prior; Peter Petzelbauer; Christian Fiala; Stefan Hacker; Alice Schöppl; Erwin Tschachler; Adelheid Elbe-Bürger Toll-like receptors (TLRs) initiate innate immune responses and direct subsequent adaptive immunity. They play a major role in cutaneous host...
View article titled, Age-related changes in expression and function of <span class="search-highlight">Toll</span>-<span class="search-highlight">like</span> <span class="search-highlight">receptors</span> in human skin
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Includes: Supplementary data
Journal Articles

Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization

Masayuki Shimada, Yoshiari Yanai, Tetsuji Okazaki, Noritaka Noma, Ikkou Kawashima, Takahide Mori, JoAnne S. Richards
Journal: Development
Development (2008) 135 (11): 2001–2011.
https://doi.org/10.1242/dev.020461
Published: 1 June 2008
...Masayuki Shimada; Yoshiari Yanai; Tetsuji Okazaki; Noritaka Noma; Ikkou Kawashima; Takahide Mori; JoAnne S. Richards The toll-like receptor (TLR) system is expressed in cumulus cells of ovulated cumulus-oocyte complexes (COCs) and is activated by bacterial lipopolysaccharides (LPS). However...
View article titled, Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization
Open the PDF for Hyaluronan fragments generated by sperm-secreted hyaluronidase stimulate cytokine/chemokine production via the TLR2 and TLR4 pathway in cumulus cells of ovulated COCs, which may enhance fertilization in another window
Includes: Supplementary data
Journal Articles

Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells

Antti Seppo, Parul Matani, Mary Sharrow, Michael Tiemeyer
Journal: Development
Development (2003) 130 (7): 1439–1448.
https://doi.org/10.1242/dev.00347
Published: 1 April 2003
... of the Toll-like receptor family, is altered on the TM3 chromosome. In wild-type embryos, Tollo/Toll-8 is expressed by ectodermal cells that surround differentiating neurons and precedes HRP-epitope appearance. Re-introduction of Tollo/Toll-8 into null embryos rescues neural-specific glycan expression. Thus...
View article titled, Induction of neuron-specific glycosylation by Tollo&#x2F;Toll-8, a Drosophila <span class="search-highlight">Toll</span>-<span class="search-highlight">like</span> <span class="search-highlight">receptor</span> expressed in non-neural cells
Open the PDF for Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila <span class="search-highlight">Toll</span>-<span class="search-highlight">like</span> <span class="search-highlight">receptor</span> expressed in non-neural cells in another window