...-specific Sema3A knockout mouse strains by constitutive or inducible vascular endothelial cadherin-Cre-mediated gene disruption. We found that in neonatal retinas of these mice, both the number and the length of tip cell filopodia were significantly increased and the leading edge growth pattern...

...) is a major component of the extracellular matrix and functions in cell adhesion, cell spreading and cell migration. In the retina, FN is transiently expressed and assembled on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting angiogenesis. The precise function...

...Janna Krueger; Dong Liu; Katja Scholz; Anja Zimmer; Yu Shi; Christian Klein; Arndt Siekmann; Stefan Schulte-Merker; Melissa Cudmore; Asif Ahmed; Ferdinand le Noble Endothelial tip cells guide angiogenic sprouts by exploring the local environment for guidance cues such as vascular endothelial growth...