...Gautham Nair; Travis Walton; John Isaac Murray; Arjun Raj Cell differentiation and proliferation are coordinated during animal development, but the link between them remains uncharacterized. To examine this relationship, we combined single-molecule RNA imaging with time-lapse microscopy to generate...

.... Remarkably, transient manipulation at appropriate times during embryogenesis led to aberrant epigenetic modifications in the ensuing adults regardless of the modification patterns, target gene sequences or locations, and despite lineage-specific epigenetic programming that could reverse the epigenetic...

... the tailless homolog nhr-67 as a cell-autonomous, stage-specific regulator of timing in LC migration programs. In nhr-67 -deficient animals, each of the L3 and L4 stage changes is either severely delayed or never occurs, yet LC development before the early L3 stage or after the mid-L4 stage occurs with normal...

...Martin F. Offield; Nicolas Hirsch; Robert M. Grainger ABSTRACT The generation of reporter lines for observing lens differentiation in vivo demonstrates a new strategy for embryological manipulation and allows us to address a long-standing question concerning the timing of the onset...

... in the egg devoted to different parts of the body can be greatly influenced. 19 11 1986 © 1987 by Company of Biologists 1987 gastrulation precleavage events pattern formation Xenopus laevis timing gravity reorientation twinning It is becoming clear from recent work...