... p38/MAPK) to invade the host ( Clarke et al., 2011 ). This increase in leakiness of the epithelium, characterised by a decrease in expression of the tight junction-associated claudins, as well as an increase in SNAI1 expression (a transcriptional repressor of claudins), could allow egress of immune...

... unknown. Here, we show that germ plasm localization in zebrafish is similar to that in Xenopus but distinct from Drosophila . We identified non muscle myosin II (NMII) and tight junction (TJ) components, such as ZO2 and claudin-d (Cldn-d) as interaction candidates of Bucky ball (Buc), which is the germ...

... Tight junctions Adherens junctions Interkinetic nuclear migration Midbrain Chick During neurulation, a flat neural plate rolls up to form a closed neural tube. This process involves diverse cell behaviors at specialized regions of the neural plate called hinge points (HPs...

... in the ATP α α and nrv2 β subunits of the Na + /K + ATPase cause Drosophila tracheal tubes to have increased lengths and expanded diameters. ATP αand nrv2 mutations also disrupt stable formation of septate junctions, structures with some functional and molecular similarities to vertebrate tight junctions...

... of water. Despite its importance in survival, the mechanisms involved in the formation and maintenance of the EPB are not well understood. To address the possibility that claudins, a new superfamily of tight junctional molecules, are involved, we engineered transgenic mice with claudin 6 (Cldn6...

...Tom P. Fleming; Mark Hay; Qamar Javed; Sandra Citi ABSTRACT The molecular maturation of the tight junction in the mouse early embryo has been investigated by monitoring the distribution of cingulin, a 140 10 3 M r peripheral (cytoplasmic) membrane constituent of the junction, at different stages...

...Qamar Javed; Tom P. Fleming; Mark Hay; Sandra Citi ABSTRACT The expression of the tight junction peripheral membrane protein, cingulin (140 10 3 M r ), was investigated in mouse eggs and staged preimplantation embryos by immunoblotting and immunoprecipitation. Polyclonal antibody to chicken brush...

.... The maturation of structural intercellular junctions is considered in more detail. Tight junction formation, essential for blastocoele cavitation and vectorial transport activity, begins at compaction (8-cell stage) and appears complete before fluid accumulation begins a day later (approx 32-cell stage). During...