... of Flk1 transcripts, essentially equivalent to background levels. However, co-expression of KLF2 and ERG resulted in strong, synergistic activation of Flk1 expression to∼25-fold above background levels. Strong activation was also observed for the vascular-specific angiopoietin receptor gene Tie2...

... Hematopoiesis Vasculogenesis Angioblast Hemangioblast Flk1 Tie2 CD31 Oct3/4 Hematopoiesis in the mouse begins in the blood islands of the yolk sac (YS)at E7.5 ( Haar and Ackerman,1971 ; Moore and Metcalf,1970 ). Nucleated red blood cells in blood islands produce embryonic globins ( Barker,1968...

... molecules specifically expressed by arterial or venous endothelial cells. We here analysed the expression of neuropilin-1 and TIE2, two transmembrane receptors known to play a role in vascular development. In birds, neuropilin-1 was expressed by arterial endothelium and wall cells, but absent from veins...