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Keywords: Thymus
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Journal: Development
Development (2024) 151 (14): dev202730.
Published: 22 July 2024
...Zhongyao Ma; Seung Woo Kang; Brian G. Condie; Nancy R. Manley ABSTRACT Thymic epithelial cells (TECs) are crucial to the ability of the thymus to generate T cells for the adaptive immune system in vertebrates. However, no in vitro system for studying TEC function exists. Overexpressing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.202853.
Published: 19 July 2024
... remain largely underdeveloped. Here we established organoids from the thymus, the lymphoid organ responsible for T cell development. We identified conditions enabling thymic epithelial progenitor cell proliferation and development into organoids with diverse cell populations and transcriptional profiles...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (8): dev200995.
Published: 21 April 2023
... investigated a K5.Foxn1 transgene that drives overexpression in mouse TECs, but causes neither hyperplasia nor delay or prevention of aging-related involution. Similarly, this transgene cannot rescue thymus size in Foxn1 lacZ/lacZ mice, which undergo premature involution as a result of reduced Foxn1 levels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200513.
Published: 26 May 2022
...Pedro Ferreirinha; Ruben G. R. Pinheiro; Jonathan J. M. Landry; Nuno L. Alves ABSTRACT The thymus stroma constitutes a fundamental microenvironment for T-cell generation. Despite the chief contribution of thymic epithelial cells, recent studies emphasize the regulatory role of mesenchymal cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (15): dev199754.
Published: 29 July 2021
... to maintain normal T-cell development and homeostasis of thymic and spleen Treg populations. Conditional deletion of Foxa1 and Foxa2 from TECs increased the proportion of medullary TECs, but reduced cell-surface MHCII expression on TECs, leading to a smaller thymus with a reduction in conventional CD4 T-cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192203.
Published: 7 October 2020
.... , Thompson , P. K. and Zúñiga-Pflücker , J. C. ( 2019 ). RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors . Nat. Immunol.   20 , 1456 - 1468 . 10.1038/s41590-019-0518-7 Ci , W. , Polo , J. M. , Cerchietti , L. , Shaknovich...
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Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
.../ Summary: Medullary thymic epithelial cell lineage specification and progenitor formation in the fetal thymus require notch signaling via notch 1 receptors, whereas further differentiation requires notch 1 to be downregulated. Foxn1 Notch Lineage mTEC Thymus Notch signaling is a highly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4027–4037.
Published: 1 November 2016
...Virginia E. Bain; Julie Gordon; John D. O'Neil; Isaias Ramos; Ellen R. Richie; Nancy R. Manley The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that S hh null mice have smaller, aparathyroid primordia in which thymus fate specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3697–3708.
Published: 1 October 2014
.... Previous studies have shown that the Hoxa3 null mutant lacks third pharyngeal pouch derivatives, the thymus and parathyroids by E18.5, and organ-specific markers are absent or downregulated during initial organogenesis. Our current analysis of the Hoxa3 null mutant shows that organ-specific domains did...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2950–2958.
Published: 1 August 2014
...Kaitlin A. G. Reeh; Kim T. Cardenas; Virginia E. Bain; Zhijie Liu; Micheline Laurent; Nancy R. Manley; Ellen R. Richie The thymus and parathyroid glands arise from a shared endodermal primordium in the third pharyngeal pouch (3rd pp). Thymus fate is specified in the ventral 3rd pp between E9.5...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (18): 3865–3878.
Published: 15 September 2011
...Julie Gordon; Nancy R. Manley The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade...
Journal Articles
Journal: Development
Development (2011) 138 (2): 339–348.
Published: 15 January 2011
...Tadashi Okubo; Akinori Kawamura; Jun Takahashi; Hisato Yagi; Masae Morishima; Rumiko Matsuoka; Shinji Takada The pharyngeal apparatus is a transient structure that gives rise to the thymus and the parathyroid glands and also contributes to the development of arteries and the cardiac outflow tract...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3587–3595.
Published: 15 September 2006
.... We show that some organs, e.g. the thymus, require Tbx1 expression in the mesoderm and in the epithelia. In addition, these experiments revealed that different pharyngeal arches require Tbx1 in different tissues. Finally, we show that Tbx1 in the mesoderm is required to sustain cell proliferation...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2041–2051.
Published: 15 May 2006
... ). As fetal thymocytes normally use γ/δ T cell receptors, it was surprising to find that TCRαβ lymphocytes predominated in co-cultures initiated with P-Sp/AGM cells. However, addition of IL7 to the cultures enhanced production of TCRγδ + cells. Cytokine concentrations in early fetal versus later thymuses...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (13): 3033–3044.
Published: 1 July 2002
... and early postnatal thymuses of C57BL/6 and AKR strain mice. Am. J. Anat . 116 , 611 -630. Strachan, T. and Read, A. P. ( 1994 ). PAX genes. Curr. Opin. Gen. Dev . 4 , 427 -438. Stuart, E. T., Kioussi, C. and Gruss, P. ( 1994 ). Mammalian Pax genes. Ann. Rev. Genet . 28 , 219 -236...
Journal Articles
Journal: Development
Development (2000) 127 (8): 1583–1591.
Published: 15 April 2000
... . Int. Immunol . 7 , 435 – 448 . 10.1093/intimm/7.3.435 Wekerle , H. , Ketelsen , U.-P. and Ernst , M. ( 1980 ). Thymic nurse cells: Lymphoepithelial cell complexes in murine thymuses. Morphological and serological characterization . J. Exp. Med . 151 , 925 – 944...
Journal Articles
Journal: Development
Development (1996) 122 (1): 23–30.
Published: 1 January 1996
... in the embryonic thymus has been reported previously. Here we show that Pax1 protein expression in thymic epithelial cells can be detected throughout thymic development and in the adult. Expression starts in the early endodermal epithelium lining the foregut region and includes the epithelium of the third...