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Keywords: Thymus
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Journal Articles
Journal: Development
Development (2021) 148 (15): dev199754.
Published: 29 July 2021
... factors Foxa1 and Foxa2 are required for positive selection during T-cell development in the thymus for regulation of RNA splicing. Foxa1 Foxa2 T-cell development RNA splicing Positive selection Thymus Mouse Medical Research Council http://dx.doi.org/10.13039/501100007155 MR...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192203.
Published: 07 October 2020
... - 302 . 10.1038/nature04882 Chen , E. L. Y. , Thompson , P. K. and Zúñiga-Pflücker , J. C. ( 2019 ). RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors . Nat. Immunol.   20 , 1456 - 1468 . 10.1038/s41590-019-0518-7 Ci...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
...Dong Liu; Anastasia I. Kousa; Kathy E. O'Neill; Paul Rouse; Martyna Popis; Alison M. Farley; Simon R. Tomlinson; Svetlana Ulyanchenko; Francois Guillemot; Philip A. Seymour; Mette C. Jørgensen; Palle Serup; Ute Koch; Freddy Radtke; C. Clare Blackburn ABSTRACT Thymus function depends...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178988.
Published: 22 June 2020
.../ Summary: Medullary thymic epithelial cell lineage specification and progenitor formation in the fetal thymus require notch signaling via notch 1 receptors, whereas further differentiation requires notch 1 to be downregulated. Foxn1 Notch Lineage mTEC Thymus Notch signaling is a highly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4027–4037.
Published: 01 November 2016
...Virginia E. Bain; Julie Gordon; John D. O'Neil; Isaias Ramos; Ellen R. Richie; Nancy R. Manley The thymus and parathyroids develop from third pharyngeal pouch (3rd pp) endoderm. Our previous studies show that S hh null mice have smaller, aparathyroid primordia in which thymus fate specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3697–3708.
Published: 01 October 2014
.... Previous studies have shown that the Hoxa3 null mutant lacks third pharyngeal pouch derivatives, the thymus and parathyroids by E18.5, and organ-specific markers are absent or downregulated during initial organogenesis. Our current analysis of the Hoxa3 null mutant shows that organ-specific domains did...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2950–2958.
Published: 01 August 2014
...Kaitlin A. G. Reeh; Kim T. Cardenas; Virginia E. Bain; Zhijie Liu; Micheline Laurent; Nancy R. Manley; Ellen R. Richie The thymus and parathyroid glands arise from a shared endodermal primordium in the third pharyngeal pouch (3rd pp). Thymus fate is specified in the ventral 3rd pp between E9.5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3456–3466.
Published: 15 September 2012
...Jennifer R. Gardiner; Abigail L. Jackson; Julie Gordon; Heiko Lickert; Nancy R. Manley; M. Albert Basson The thymus and parathyroid glands are derived from the third pharyngeal pouch endoderm. The mechanisms that establish distinct molecular domains in the third pouch and control the subsequent...
Journal Articles
Journal: Development
Development (2011) 138 (18): 3865–3878.
Published: 15 September 2011
...Julie Gordon; Nancy R. Manley The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade...
Journal Articles
Journal: Development
Development (2011) 138 (2): 339–348.
Published: 15 January 2011
...Tadashi Okubo; Akinori Kawamura; Jun Takahashi; Hisato Yagi; Masae Morishima; Rumiko Matsuoka; Shinji Takada The pharyngeal apparatus is a transient structure that gives rise to the thymus and the parathyroid glands and also contributes to the development of arteries and the cardiac outflow tract...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3587–3595.
Published: 15 September 2006
.... We show that some organs, e.g. the thymus, require Tbx1 expression in the mesoderm and in the epithelia. In addition, these experiments revealed that different pharyngeal arches require Tbx1 in different tissues. Finally, we show that Tbx1 in the mesoderm is required to sustain cell proliferation...
Journal Articles
Journal: Development
Development (2006) 133 (10): 2041–2051.
Published: 15 May 2006
... in co-cultures initiated with P-Sp/AGM cells. However, addition of IL7 to the cultures enhanced production of TCRγδ + cells. Cytokine concentrations in early fetal versus later thymuses might account in part for the TCR rearrangement and selection events needed to generate these two major types of T...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (25): 6361–6374.
Published: 22 December 2003
... and septation, disrupted pharyngeal vascular development, and abnormal formation of the thymus and parathyroids( Abu-Issa et al., 2002 ; Frank et al., 2002 ). These Fgf8 hypomorphs phenocopy human syndromes associated with deletion of chromosome 22q11 (del22q11) such as DiGeorge syndrome( Epstein, 2001...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3033–3044.
Published: 01 July 2002
... Eya1 impairs early developmental processes in multiple organs, including ear, kidney and skeletal system. We have now examined the role of Eya1 during the morphogenesis of organs derived from the pharyngeal region, including thymus, parathyroid and thyroid. The thymus and parathyroid are derived from...