... differentiation and promoting precocious lactation during pregnancy. This in turn, results in milk stasis and premature involution of the gland mediated by the activation of Stat3 and Tgfβ3. We further show that epithelial differentiation is only accelerated when MYC is expressed within a discrete 72-hour period...

... (Erlebacher et al., 1998 ; Friess et al., 1998 ; Lehrmann et al., 1998 ; Lenz et al., 1998 ; Martin et al., 1998) and with the morphological changes seen in the lactating mammary glands of the TGFβ3 transgenic mice. Previous studies have established that milk stasis induces a local factor...