... in lens morphogenesis and denucleation of lens fibers. Lens Terminal differentiation Smarca4 Brg1 Smarca5 Snf2h Denucleation Cataract ATP-dependent chromatin remodeling is required for transcription, DNA replication, DNA repair and genetic recombination ( de la Serna et al., 2006...

... the transition to quiescence in terminally differentiating tissues. (A,B) Dominant-negative wdb ( wdb DN ) was expressed in the posterior wing from mid-L3 using engrailed-Gal4/Gal80 TS . Pupal tissues were labeled with EdU for 1 h at 23 h APF to visualize S phases (A) or labeled with anti-PH3 at 26 h APF...

...Guangdi Zhou; Xuchao Jiang; Hai Zhang; Yinzhong Lu; Anjun Liu; Xianhua Ma; Guan Yang; Rui Yang; Hongxing Shen; Jianming Zheng; Yiping Hu; Xiao Yang; Weiping J. Zhang; Zhifang Xie The terminal differentiation of hypertrophic chondrocytes is a tightly regulated process that plays a pivotal role...

... of the NB5-6 lineage, we analyzed the terminal differentiation markers Nplp1 and FMRFa, which are neuropeptides expressed by Ap1 and Ap4, respectively. Whereas Nplp1 expression was largely unaffected in klu embryos ( Fig. 1F,L,P,Q ), we found an almost complete loss of FMRFa in the lateral thoracic areas...

...David T. Harris; H. Robert Horvitz In Caenorhabditis elegans , a well-defined pathway of heterochronic genes ensures the proper timing of stage-specific developmental events. During the final larval stage, an upregulation of the let-7 microRNA indirectly activates the terminal differentiation...

... neuronal processes such as neuronal patterning, axon outgrowth and terminal differentiation, opens up new avenues to study the properties of mdDA neurons during development and in neuronal pathology as observed in Parkinson's disease. Developmental pathways Dopamine mdDA Midbrain Terminal...

... 5 6 2003 © 2003. 2003 Homeodomain Photoreceptor Rhabdomere Phototransduction Terminal differentiation Hazy Drosophila Drosophila photoreceptor cell specification and differentiation occurs over a 120 hour period. We have considerable insight into the regulatory...

... invagination, and becomes highly upregulated in the equatorial zone, the site at which self-renewing anterior epithelial cells withdraw from the cell cycle and terminally differentiate into posterior fiber cells. Posterior lens cells in Maf lacZ mutant mice exhibit failure of elongation at embryonic day 11.5...

...Jill C. Bettinger; Kimberly Lee; Ann E. Rougvie ABSTRACT The Caenorhabditis elegans gene lin-29 is required for the terminal differentiation of the lateral hypodermal seam cells during the larval-to-adult molt. We find that lin-29 protein accumulates in the nuclei of these cells, consistent...

...Ann E. Rougvie; Victor Ambros ABSTRACT A hierarchy of heterochronic genes, lin-4, lin-14, lin-28 and lin-29 , temporally restricts terminal differentiation of Caenorhabditis elegans hypodermal seam cells to the final molt. This terminal differentiation event involves cell cycle exit, cell fusion...

...Neil A. Hopper; Christophe Anjard; Christophe D. Reymond; Jeffrey G. Williams ABSTRACT Expression of the catalytic (C) subunit of the cAMP-dependent protein kinase (PKA) of Dictyostelium under the control of heterologous, cell-type-specific promoters causes ectopic terminal differentiation. When...