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Keywords: Teratomas
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Journal Articles

Testicular germ cell tumors arise in the absence of sex-specific differentiation

Nicholas J. Webster, Rebecca L. Maywald, Susan M. Benton, Emily P. Dawson, Oscar D. Murillo, Emily L. LaPlante, Aleksandar Milosavljevic, Denise G. Lanza, Jason D. Heaney
Journal: Development
Development (2021) 148 (9): dev197111.
https://doi.org/10.1242/dev.197111
Published: 28 April 2021
....MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ...
View articletitled, Testicular germ cell tumors arise in the absence of sex-specific differentiation
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Includes: Supplementary data
Journal Articles

Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency

Emily P. Dawson, Denise G. Lanza, Nicholas J. Webster, Susan M. Benton, Isao Suetake, Jason D. Heaney
Journal: Development
Development (2018) 145 (6): dev156612.
https://doi.org/10.1242/dev.156612
Published: 15 March 2018
...Emily P. Dawson; Denise G. Lanza; Nicholas J. Webster; Susan M. Benton; Isao Suetake; Jason D. Heaney Testicular teratomas result from anomalies in embryonic germ cell development. In 129 inbred mice, teratoma initiation coincides with germ cell sex-specific differentiation and the mitotic-meiotic...
View articletitled, Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency
Open the PDF for Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency in another window
Includes: Supplementary data