..., such as a loss of epithelial tension and changes in junctional actomyosin. Changes upon IRAK-4 inhibition are conserved in human bronchial epithelial cells. Knockdown of IRAK4 and certain TLRs phenocopies the inhibitor treatment. These data suggest a model whereby TLR receptors near epithelial junctions might...

.... Summary: Zasp52 is a key component of supracellular actomyosin cables during epithelial morphogenesis that serve to insulate morphogenetic changes from each other. Actomyosin Supracellular cable Junctions Cytoskeleton Tension Epithelium Morphogenesis Medical Research Council http...

... neuroectoderm of Xenopus laevis and investigated how mechanical signals regulate polarity. We reveal that the neuroectoderm is under a greater tension in the anterior-posterior direction and that perturbation of this tension causes PCP disappearance. We show that application of uniaxial stretch to explant...

... are tension-responsive proteins involved in myogenic versus adipogenic differentiation . Dev. Cell 9 , 39 - 49 . 10.1016/j.devcel.2005.04.015 Jaslove , J. M. and Nelson , C. M. ( 2018 ). Smooth muscle: a stiff sculptor of epithelial shapes . Philos. Trans. R. Soc. Lond. B Biol. Sci...

... to reflect directional tension that drives oriented cell intercalations. We have characterised and applied a recently introduced non-destructive optical manipulation technique to measure the tension in individual epithelial cell junctions of cells in various locations and orientations in the epiblast...

... and cell layer are progressively uncoupled. Concomitantly, the tension, mainly borne by the ECM at first, builds up in the cell monolayer. Then, each layer of the peripodial epithelium is removed by an independent mechanism: while the ECM layer withdraws following local proteolysis, cellular monolayer...

... Myosin Tension In On Growth and Form , D'Arcy Thompson proposed that an organism's form is a ʻdiagram of the forces' that have acted and continue to act upon it ( Thompson, 1917 ). At the time of its publication, what those forces were and how they were generated was a mystery. However, 100...

... demonstrate that mechanical tension precedes the formation of the immature myofibrils. Moreover, these immature myofibrils do generate spontaneous Ca 2+ -dependent contractions in vivo , which, when chemically blocked, result in cross-striation defects. Taken together, these results suggest...

...-cadherin enhanced it. Laser ablation experiments revealed that lens epithelium is governed by pulling tension, which is modulated by these cadherins. Thus, cell division and cadherin-mediated adhesion regulate lens epithelial cell movement via modulation of epithelial tension. * Author...

... that includes the mammalian p115-RhoGEF and LARG ( Mulinari and Hacker, 2010 ), the latter of which is activated by tensional forces exerted on focal adhesion complexes in mammalian cells in culture ( Guilluy et al., 2011 ). Furthermore, the levels of E-cadherin within the stalk cells are also controlled...

... by mechanical cues and forces. References Ahmed W. W. , Li T. C. , Rubakhin S. S. , Chiba A. , Sweedler J. V. , Saif T. A. ( 2012 ). Mechanical tension modulates local and global vesicle dynamics in neurons . Cell. Mol. Bioeng. 5 , 155 – 164 . Amin L...

... . EMBO J. 27 , 2829 - 2838 . Anava S. , Greenbaum A. , Ben Jacob E. , Hanein Y. , Ayali A. ( 2009 ). The regulative role of neurite mechanical tension in network development . Biophys. J. 96 , 1661 - 1670 . Anderson D. C. , Gill J. S. , Cinalli R...