... Atf3, they often result in direct neuronal generation. Adult neural stem cells Telencephalon Pallium Zebrafish Direct fate conversion Apoptosis Caspase Atf3 Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 Ligue Contre le Cancer http...

... in the embryonic zebrafish telencephalon. Using a homozygote endogenous Her6:Venus reporter and 4D single-cell tracking, we show that Her6 oscillates in neural telencephalic progenitors and that the fusion of protein destabilisation (PEST) domain alters its expression dynamics, causing most cells to downregulate...

... understood. Here, we report that the telencephalon-specific loss of PAR3 before the start of neurogenesis leads to increased NPC proliferation at the expense of neurogenesis, resulting in disorganized tissue architecture. These NPCs demonstrate hyperactivation of hedgehog signaling in a smoothened-dependent...

.... All these features show significant variations in the cavefish natural mutant. We also discover sub-domains within the prospective telencephalon and characterize cell identities at the frontiers of the eye field. We propose putative fates for some of the characterized eye-field subdivisions...

... in the telencephalon of developing amphibian embryos. The loss of Rab11fip5 function causes a reduction in telencephalon size and a decrease in the expression level of ephrinB1. Moreover, morpholino oligonucleotide-mediated knockdown of Rab11fip5 decreases cell proliferation in the telencephalon. The overexpression...

.... E-protein Proximity ligation assay Subapical progenitor Tcf3 Telencephalon National Institutes of Health R01 NS044080 NS069893 Chan Zuckerberg Initiative 2017-173968 Throughout evolution, the mammalian telencephalon, including both the cerebral cortex...

... telencephalon. Thus, we prospectively isolated adult newborn neurons from the adult zebrafish forebrain, identified markers for newborn and mature neurons in the adult brain, and revealed intrinsic heterogeneity among adult newborn neurons and their homology with mammalian adult neurogenic cell types...

... forebrain development. Cux2 Lmx1a Cortical hem Corticogenesis Enhancer Telencephalon Children's Hospital Colorado 10.13039/100007180 Boettcher Foundation 10.13039/100005508 During forebrain development, neural progenitor cells give rise to many different types...

... by the transcription factor FOXG1 acting directly and also by positively regulating LHX2. LHX2 FOXG1 Telencephalon Patterning Hippocampus Hem Mouse Wellcome Trust – Department of Biotechnology India Alliance 10.13039/100004440 IA/E/11/1/500402 Department of Biotechnology, Ministry...

... and craniofacial tissues. In particular, this ablation compromises the development of the telencephalon without affecting that of the diencephalon. Further investigations of ablated mouse embryos established that signalling centres crucial for forebrain regionalization, namely the axial mesendoderm...

... interests. 15 10 2013 25 11 2013 © 2014. Published by The Company of Biologists Ltd 2014 LPAR6 FGF ENPP2 Forebrain Telencephalon Xenopus Lysophosphatidic acid (LPA) is a small ubiquitous phospholipid that acts as an extracellular signal and is believed...

... ventral telencephalon. In the absence of Gsx2 expression, an increase in oligodendrocyte precursor cells (OPCs) with a concomitant decrease in neurogenesis is observed in the subventricular zone of the LGE at mid-stages of embryogenesis (i.e. E12.5-15.5), which subsequently leads to an increased number...

... hypomorphic mutations in human and mouse can promote holoprosencephaly (HPE), a forebrain malformation that results, at least in part, from abnormal telencephalon development. However, the roles of Six3 in telencephalon patterning and differentiation are not well understood. To address the role of Six3...

...Luisa Sanchez-Arrones; Claudio D. Stern; Paola Bovolenta; Luis Puelles The anterior border of the neural plate, presumed to contain the prospective peripheral portion (roof) of the prospective telencephalon, emerges within a vaguely defined proneural ectodermal region. Fate maps carried out at HH4...

... Forebrain patterning Telencephalon Transcriptional regulation Medaka Vertebrate fate mapping studies have established that the telencephalon, the retinal anlage and the ventral hypothalamus derive from adjacent domains in the anterior neural plate (ANP) ( Sanchez-Arrones et al., 2009...

... that is severely affected in human ciliopathies. Here, we study telencephalic morphogenesis in a mouse mutant for the ciliopathy gene Ftm ( Rpgrip1l ). We show that the olfactory bulbs are present in an ectopic location in the telencephalon of Ftm −/− fetuses and do not display morphological outgrowth at the end...

...Fumiaki Sugahara; Shin-ichi Aota; Shigehiro Kuraku; Yasunori Murakami; Yoko Takio-Ogawa; Shigeki Hirano; Shigeru Kuratani Dorsoventral (DV) specification is a crucial step for the development of the vertebrate telencephalon. Clarifying the origin of this mechanism will lead to a better...

... ; Ghanem et al., 2007 ; Zerucha et al., 2000 ) ( Fig. 2B ). In the telencephalon of E11.5 mouse embryos, I56i targets lacZ expression to the subventricular zone (SVZ) and mantle zone (MZ) of the medial and lateral ganglionic eminences (MGE and LGE) ( Fig. 2C ). By contrast, lacZ expression driven...

... conserved among tetrapods and unexpectedly directed all the Emx2 expression in forebrain: caudal forebrain primordium at E8.5, dorsal telencephalon at E9.5-E10.5 and the cortical ventricular zone after E12.5. Otx, Tcf, Smad and two unknown transcription factor binding sites were essential to all...

...Martin Roth; Boyan Bonev; Jennefer Lindsay; Robert Lea; Niki Panagiotaki; Corinne Houart; Nancy Papalopulu FoxG1 is a conserved transcriptional repressor that plays a key role in the specification, proliferation and differentiation of the telencephalon, and is expressed from the earliest stages...