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Keywords: Tectum
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Journal Articles
Journal: Development
Development (2011) 138 (12): 2457–2465.
Published: 15 June 2011
... in the nucleus, and deployment of guidance and adhesion cues to the cell surface. To identify genes involved in neurite targeting by retinal ganglion cells (GCs), their presynaptic partners in the retina, and their postsynaptic targets in the optic tectum, we undertook a forward genetic screen for mutations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2325–2335.
Published: 15 June 2007
... are candidate regulators of this process in the dorsal midbrain (tectum) and anterior hindbrain (cerebellum). En1 mutants lack most of the tectum and cerebellum and die at birth, whereas En2 mutants are viable with a smaller cerebellum and foliation defects. Our previous studies indicated that the difference...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (4): 735–746.
Published: 15 February 2007
... midbrain, the future optic tectum. Wnts act both as patterning signals and as regulators of cell growth. In the developing tectum, Wnt signaling is mitogenic; however, the mechanism of Wnt function is not known. As a step towards better understanding this mechanism, we have identified two new Wnt targets...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (2): 317–325.
Published: 15 January 2007
...-specific conditional knockout of Lmx1b . As a result of these molecular defects, the development of the tectum and cerebellum was severely impaired in Lmx1b -/- mice. Taken together, our results indicate that Lmx1b plays an essential role in the development of the tectum and cerebellum by regulating...
Journal Articles
Journal: Development
Development (2005) 132 (13): 2955–2967.
Published: 01 July 2005
... a distinct subset of retinal ganglion cells (RGCs),which project mainly into one of the four retinorecipient layers of the tectum and into a small subset of the extratectal arborization fields. In this transgenic line, we carried out an ENU-mutagenesis screen by scoring live zebrafish larvae for anatomical...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (17): 4275–4285.
Published: 01 September 2004
...Tatsuya Sato; Harukazu Nakamura The mes/metencephalic boundary (isthmus) is an organizing center for the optic tectum and cerebellum. Fgf8 is accepted as a crucial organizing signal. Previously, we reported that Fgf8b could induce cerebellum in the mesencephalon, while Fgf8a transformed...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5201–5212.
Published: 15 December 2001
... neocortex and tectum, whereas the Gli genes, which are targets and mediators of SHH signaling, are expressed in proliferative zones. In vitro and in vivo assays show that SHH is a mitogen for neocortical and tectal precursors and that it modulates cell proliferation in the dorsal brain. Together with its...
Journal Articles
Journal: Development
Development (2001) 128 (20): 4069–4077.
Published: 15 October 2001
...Eiji Matsunaga; Isato Araki; Harukazu Nakamura Pax3/7 is expressed in the alar plate of the mesencephalon. The optic tectum differentiates from the alar plate of the mesencephalon, and expression of Pax3/7 is well correlated to the tectum development. To explore the function of Pax3 and Pax7...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2461–2469.
Published: 01 July 2001
..., the cerebellum differentiates in the metencephalon and the tectum differentiates in the mesencephalon. Based on the assumption that strong Fgf8 signal induces the cerebellum and that the Fgf8b signal is stronger than that of Fgf8a, we carried out experiments to misexpress Fgf8b and Fgf8a in chick embryos. Fgf8a...