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Keywords: Tead
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Journal Articles
Journal: Development
Development (2021) 148 (12): dev196675.
Published: 15 June 2021
... by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD...
Journal Articles
Journal: Development
Development (2008) 135 (24): 4059–4069.
Published: 15 December 2008
...Mitsunori Ota; Hiroshi Sasaki Regulation of organ size is important for development and tissue homeostasis. In Drosophila, Hippo signaling controls organ size by regulating the activity of a TEAD transcription factor, Scalloped, through modulation of its co-activator protein Yki. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4719–4729.
Published: 1 November 2005
... motifs within the CE. These same motifs were also required for enhancer activity in transgenic embryos. We identified the Tead family of transcription factors as binding proteins for the 3′motif. Teads and their co-factor YAP65 activated the CE in P19 cells, and binding of Tead to CE was essential...
Includes: Supplementary data