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Keywords: Tbx4
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Journal Articles
Journal: Development
Development (2021) 148 (19): dev199580.
Published: 24 September 2021
...Veronique Duboc; Fatima A. Sulaiman; Eleanor Feneck; Anna Kucharska; Donald Bell; Muriel Holder-Espinasse; Malcolm P. O. Logan ABSTRACT We dissect genetically a gene regulatory network that involves the transcription factors Tbx4 , Pitx1 and Isl1 acting cooperatively to establish the hindlimb bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev159830.
Published: 22 March 2018
...Deepak Jain; Stephen Nemec; Maëva Luxey; Yves Gauthier; Amandine Bemmo; Aurelio Balsalobre; Jacques Drouin ABSTRACT In tetrapods, Tbx4 , Tbx5 and Hox cluster genes are crucial for forelimb and hindlimb development and mutations in these genes are responsible for congenital limb defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5301–5309.
Published: 15 December 2011
... is also necessary for normal expression of Tbx4, a transcription factor required for normal hindlimb development. Despite the importance of this protein in these processes, little is known about its mechanism of action. Using a transgenic gene replacement strategy in a Pitx1 mutant mouse, we have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (15): 2543–2553.
Published: 1 August 2008
...Douglas B. Menke; Catherine Guenther; David M. Kingsley The Tbx4 transcription factor is crucial for normal hindlimb and vascular development, yet little is known about how its highly conserved expression patterns are generated. We have used comparative genomics and functional scanning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (1): 93–103.
Published: 1 January 2007
...L. A. Naiche; Virginia E. Papaioannou Tbx4 is a crucial gene in the initiation of hindlimb development and has been reported as a determinant of hindlimb identity and a presumptive direct regulator of Fgf10 in the limb. Using a conditional allele of Tbx4 , we have ablated Tbx4 function before...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2729–2739.
Published: 15 June 2003
...Jun K. Takeuchi; Kazuko Koshiba-Takeuchi; Takayuki Suzuki; Mika Kamimura; Keiko Ogura; Toshihiko Ogura A tight loop between members of the fibroblast growth factor and the Wnt families plays a key role in the initiation of vertebrate limb development. We show for the first time that Tbx5 and Tbx4...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2681–2693.
Published: 15 June 2003
...L. A. Naiche; Virginia E. Papaioannou Tbx4 is a member of the T-box family of transcription factor genes, which have been shown to play important roles in development. We have ablated Tbx4 function using targeted mutagenesis in the mouse. Embryos homozygous for the null allele fail to undergo...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1225–1234.
Published: 1 April 2003
... endoderm formation. Tbx4 , a member of the T-box transcription factor gene family, was specifically expressed in the visceral mesoderm of the lung primordium. To analyze the function of Tbx4, we ectopically expressed Tbx4 in the visceral mesoderm of the foregut using in ovo electroporation. Ectopic Tbx4...
Journal Articles
Journal: Development
Development (2002) 129 (1): 211–220.
Published: 1 January 2002
...Daisuke Saito; Sayuri Yonei-Tamura; Kohko Kano; Hiroyuki Ide; Koji Tamura Limb-type-specific expression of Tbx5/Tbx4 plays a key role in drawing distinction between a forelimb and a hindlimb. Here, we show insights into specification and determination during commitment of limb-type identity...