...Rajiv A. Mohan; Mathilda T. M. Mommersteeg; Jorge N. Domínguez; Caroline Choquet; Vincent Wakker; Corrie de Gier-de Vries; Gerard J. J. Boink; Bastiaan J. Boukens; Lucile Miquerol; Arie O. Verkerk; Vincent M. Christoffels ABSTRACT A small network of spontaneously active Tbx3 + cardiomyocytes forms...

.... These rudiments expressed the mammary placode markers Wnt10b and Tbx3 and were labeled by antibodies to the mammary mesenchyme markers ERα and androgen receptor. Somitic Fgf10 expression, which is required for normal mammary line formation, was upregulated in mutant cervical somites, and conditional ablation...

... signalling regulates early positional differences of Tbx3 and Hmx1 transcription factor expression in distinct divisions of the TG (Hodge et al., 2007). Bmp4 expression is readily detected in the duplicate arrays of whisker primordia on the Edn1 −/− mutant lower jaw (Ozeki et al., 2004). We therefore...

...Atsushi Suzuki; Sayaka Sekiya; Dirk Büscher; Juan Carlos Izpisúa Belmonte; Hideki Taniguchi Although the T-box family of transcription factors function in many different tissues, their role in liver development is unknown. Here we show that Tbx3 , the T-box gene that is mutated in human ulnar...

... that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome. We provide evidence that the Tbx3 promoter is directly regulated by Bmp Smads...

...Charalampos Rallis; Jo Del Buono; Malcolm P. O. Logan The limbs of the vertebrate embryo form at precise locations along the body and these positions are fixed across different species. The mechanisms that control this process are not understood. Ectopic expression of Tbx3 ,a transcriptional...

...Todd G. Davenport; Loydie A. Jerome-Majewska; Virginia E. Papaioannou Spontanteous mutations in the T-box gene TBX3 , result in the human ulnar-mammary syndrome, a dominant developmental disorder characterized by abnormal forelimb and apocrine gland development. In order to develop a mouse model...

...-mail: [email protected]) 03 06 1998 08 04 1998 © 1998 by Company of Biologists 1998 T-box gene Tbx2 Tbx3 Tbx4 Tbx5 Limb development Limb identity Chick One of the defining features of jawed vertebrates (gnathostomes) is the development of two sets of paired...