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Keywords: Tbx20
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Journal Articles
Journal: Development
Development (2013) 140 (15): 3176–3187.
Published: 01 August 2013
... of the diverse signals that regulate endocardial cushion development and valve elongation. Here, we report that the T-box transcription factor Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development. Ablation of Tbx20 in endocardial cells causes severe valve elongation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1919–1929.
Published: 01 June 2010
...Elizabeth M. Mandel; Erin Kaltenbrun; Thomas E. Callis; Xin-Xin I. Zeng; Sara R. Marques; Deborah Yelon; Da-Zhi Wang; Frank L. Conlon TBX20 has been shown to be essential for vertebrate heart development. Mutations within the TBX20 coding region are associated with human congenital heart disease...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4945–4955.
Published: 15 December 2006
... remain poorly characterized. Tbx20 is expressed by migrating branchiomotor/visceromotor (BM/VM) neurons within the hindbrain during neuronal circuit formation. We examined Tbx20 function in BM/VM cells using conditional Tbx20 -null mutant mice to delete the gene in neurons. Hindbrain rhombomere...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2451–2462.
Published: 15 May 2005
... specification and morphogenesis of the mammalian embryonic heart are poorly understood. We now show by gene targeting that murine T-box transcription factor Tbx20 plays a central role in these pathways, and has important activities in both cardiac development and adult function. Loss of Tbx20 results in death...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2463–2474.
Published: 15 May 2005
... of the T-box transcription factor Tbx20 in mammalian development, we generated a graded loss-of-function series by transgenic RNA interference in entirely embryonic stem cell-derived mouse embryos. Complete Tbx20 knockdown resulted in defects in heart formation, including hypoplasia of the outflow tract...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2475–2487.
Published: 15 May 2005
...Chen-Leng Cai; Wenlai Zhou; Lei Yang; Lei Bu; Yibing Qyang; Xiaoxue Zhang; Xiaodong Li; Michael G. Rosenfeld; Ju Chen; Sylvia Evans Mutations in T-box genes are the cause of several congenital diseases and are implicated in cancer. Tbx20 -null mice exhibit severely hypoplastic hearts and express...
Journal Articles
Journal: Development
Development (2005) 132 (3): 553–563.
Published: 01 February 2005
... and the mechanism by which individual T-box genes function remains largely unknown. In this study, we have investigated the cellular and molecular relationship between two T-box genes, Tbx5 and Tbx20 . We demonstrate that blocking Tbx5 or Tbx20 produces phenotypes that display a high degree of similarity, as judged...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (24): 5953–5964.
Published: 15 December 2003
... cardiogenesis. When Tbx5 was misexpressed ubiquitously,ventricular septum was not formed, resulting in a single ventricle. In such heart, left ventricle (LV)-specific ANF gene was induced. In search of the putative RV factor(s), we have found that chick Tbx20 is expressed in the RV, showing a complementary...