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Keywords: Taz
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Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187187.
Published: 12 November 2020
...Hannah K. Vanyai; Fabrice Prin; Oriane Guillermin; Bishara Marzook; Stefan Boeing; Alexander Howson; Rebecca E. Saunders; Thomas Snoeks; Michael Howell; Timothy J. Mohun; Barry Thompson; Sally Dunwoodie; John Wallingford ABSTRACT The Hippo-YAP/TAZ pathway is an important regulator of tissue growth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev179069.
Published: 27 April 2020
... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies. References...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (22): dev167023.
Published: 22 November 2018
..., little is known about its role in cell fate specification and differentiation. Here, we unravel a novel and unexpected role of the Hippo pathway effector Taz ( wwtr1 ) in controlling the size, shape and fate of a unique cell in the zebrafish ovary. We show that wwtr1 mutant females are infertile...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev159210.
Published: 17 May 2018
... heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions. Heart development Hippo pathway Yap Taz Wwtr1 Trabeculation Cardiac trabeculation is an important step to cardiac...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (10): 1674–1687.
Published: 15 May 2016
... epithelium that is continuously renewed by a population of basal layer stem/progenitor cells and can heal wounds. Here, we show that the transcription regulators YAP and TAZ localise to the nucleus in the basal layer of skin and are elevated upon wound healing. Skin-specific deletion of both YAP and TAZ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2962–2971.
Published: 1 September 2015
... arteries and cranial vasculature during embryonic development. Neural crest-specific deletion of the Hippo effectors Yap and Taz produces neural crest precursors that migrate normally, but fail to produce vascular smooth muscle, and Notch target genes such as Jagged1 fail to activate normally. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2696–2703.
Published: 1 August 2015
... use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz . Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts...
Includes: Supplementary data