... genome-wide expression profiling of conditional β-catenin mutant embryos. Known Wnt/β-catenin target genes, known components of other signaling pathways, as well as a number of uncharacterized genes were downregulated in these mutants. To further narrow down the set of differentially expressed genes, we...

... hybridization screens of mRNAs between β-catenin overexpressed embryos and cadherin overexpressed embryos were conducted to identify potential β-catenin target genes that are responsible for endoderm differentiation in Ciona savignyi embryos. We found that a LIM-homeobox gene ( Cs-lhx3 ), an otx homolog ( Cs...

...Andrei V. Tkatchenko; Richard P. Visconti; Lijuan Shang; Thomas Papenbrock; Nathanael D. Pruett; Tatsuya Ito; Makio Ogawa; Alexander Awgulewitsch ABSTRACT Studying the roles of Hox genes in normal and pathological development of skin and hair requires identification of downstream target genes...

... in the selection and regulation of target genes. A major question in the field is whether these cofactor interactions select target genes by modulating DNA binding site specificity (selective binding model), transcriptional activity (activity regulation model) or both. A related issue is whether the number...

...Nuria Serrano; Hugh W. Brock; Florence Maschat ABSTRACT In Drosophila , Engrailed is a nuclear regulatory protein with essential roles during embryonic development. Although Engrailed is a transcription factor, little progress has been achieved in identifying its target genes. We report here...

... that poly-homeotic activation in germ-band-elongated embryos could be mediated by Engrailed-binding to these sites. * Author for correspondence 06 03 1995 © 1995 by Company of Biologists 1995 Drosophila engrailed polyhomeotic target genes regulation Proteins...

...James W. Mahaffey; Denise F. Jones; Jo Ann Hickel; Charles M. Griswold ABSTRACT In Drosophila , the homeotic genes encode transcription factors which control segment identity during embryogenesis by specifying the appropriate set of ‘target’ genes necessary to produce the individual segmental...