... and is directly allocated to neural and mesodermal compartments during gastrulation. A second population in the tailbud undergoes delayed allocation to contribute to the neural and mesodermal compartment only at late somitogenesis. Cell tracking and retrospective cell fate assignment at late somitogenesis stages...

... the posteriormost embryonic structure, the tailbud. It is unclear to what extent the molecular mechanisms of mesoderm induction are conserved between gastrula and post-gastrula stages of development. Fibroblast growth factor (FGF) signaling is required for mesoderm induction during gastrulation through positive...

...Richard H. Row; Steve R. Tsotras; Hana Goto; Benjamin L. Martin Vertebrate body axis formation depends on a population of bipotential neuromesodermal cells along the posterior wall of the tailbud that make a germ layer decision after gastrulation to form spinal cord and mesoderm. Despite exhibiting...

...Andrew K. Lawton; Amitabha Nandi; Michael J. Stulberg; Nicolas Dray; Michael W. Sneddon; William Pontius; Thierry Emonet; Scott A. Holley The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of motile progenitors of the axial skeleton, musculature and spinal cord...

...Yi Yang; Chris Thorpe The role of bone morphogenetic protein (BMP) signaling in specifying cell fate in the zebrafish tailbud has been well established. In addition to a loss of ventral tissues, such as ventral tailfin and cloaca, some embryos with compromised BMP signaling produce an additional...

... and tailbud-derived mesoderm, which is selectively associated with the domain of the UB that differentiates into the ureter. Functional experiments utilizing murine metanephric kidney explants show that BMP4, a paracrine factor secreted by tailbud-derived mesenchyme, is required for ureter morphogenesis...

...-mail: htakeda@biol.s.u-tokyo.ac.jp ) 29 8 2001 © 2001. 2001 Fgf Somite Segmentation Tailbud fused somites after eight her1 Zebrafish Somite formation, a process in which reiterated epithelial structures are progressively demarcated from the mesenchymal presomitic mesoderm...

...Robert L. Davis; Marc W. Kirschner ABSTRACT The vertebrate tailbud and trunk form very similar tissues. It has been a controversial question for decades whether cell determination in the developing tail proceeds as part of early axial development or whether it proceeds by a different mechanism...

...John P. Kanki; Robert K. Ho ABSTRACT In order to understand the developmental mechanisms of posterior body formation in the zebrafish, a fate map of the zebrafish tailbud was generated along with a detailed analysis of tailbud cell movements. The fate map of the zebrafish tailbud shows...

... becomes very striking at somite stages as the somites extend from the notochord around the circumference of the embryo fusing on the ventral side ( Fig. 1C,G ). The tailbud does not proceed around the yolk toward the ventral side, as in wild-type embryos, but instead extends off the yolk ( Fig. 1C,G...

... tail, a structure characteris tic of the chordates. * Author for correspondence © 1994 by Company of Biologists 1994 Spemann organizer tailbud goosecoid Brachyury Xnot-2 gastrulation Evolutionary and embryological studies have been intertwined throughout their history...

... LiCl tailbud spadetail spt Brachyury T mutation no tail ntl zebrafish Among vertebrates, the zebrafish is particularly amenable to both embryological and genetic studies of early development ( Kimmel, 1989 ; Ho, 1992 ). We have chosen this teleost to study one pivotal...

... the blastopore lip into distinct cell populations of the developing tailbud. Second, the tip of the tail retains Spemann’s tail organizer activity until late stages of development. Third, lineage studies with the tracer DiI indicate that the cells of the late blastopore are fated to form specific tissues...

... in the tail reveals that normally T is expressed highly in the tailbud (the growing portion of the tail) during its elongation between 9.5 and 11.5 dpc. Thus, evidence both from chimeras and from T expression in the tail suggest that T may play a role in the correct deployment of cells emerging from...