... Tabby Ectodysplasin Edar Salivary gland HED Branching morphogenesis NF-κB Wnt Sonic hedgehog Ectodysplasin belongs to the tumor necrosis factor (TNF) family of signaling molecules and its function has been shown to be vital for the formation of the ectodermal organs in vertebrates from...

... , and possibly follistatin, are downstream of Eda-A1 in embryonic skin. Ccn2 Ectodermal dysplasia Lateral inhibition NF-κB Tabby Mouse The first visible sign of ectodermal organ development is the appearance of an ectodermal placode, a local thickening of the epithelium. Formation...

... morphogenesis. In the mouse, the genes of the spontaneous mutations Tabby ( Ta ) and downless ( dl ) were identified as homologs of ED1 and EDAR , respectively. To gain insight into the function of this signaling pathway in development of skin and hair follicles, we analyzed the expression and regulation of Eda...

...Abigail S. Tucker; Denis J. Headon; Pascal Schneider; Betsy M. Ferguson; Paul Overbeek; Jurg Tschopp; Paul T. Sharpe ABSTRACT tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been...

...Joachim Kapalanga; Stan R. Blecher Studies on eyelid opening and incisor eruption in 216 neonatal Tabby ( Ta )-bearlng mice and wildtype controls (35 Ta /Y, 62 +/Y, 30 Ta/Ta , 57 Ta/+ and 32 +/+) showed that in animals hemizygous and homozygous for Ta , the timing of eyelid opening and incisor...