...Laura D. Mathies; Mara Schvarzstein; Kristin M. Morphy; Robert Blelloch; Andrew M. Spence; Judith Kimble TRA-1/GLI is best known as a master regulator of sex determination in the nematode C. elegans , but its fly and vertebrate homologs (e.g. Ci,GLI) regulate embryonic patterning and cell...

...Woelsung Yi; Jennifer M. Ross; David Zarkower ABSTRACT Sex determination is controlled by global regulatory genes, such as tra-1 in Caenorhabditis elegans, Sex lethal in Drosophila , or Sry in mammals. How these genes coordinate sexual differentiation throughout the body is a key unanswered...

... experiments indicate that expression of fog-3 is controlled by tra-1 . Second, studies of double mutants show that this control could be direct. Third, the fog-3 promoter contains multiple sites that bind TRA-1A in gel shift assays, and mutations in these sites alter activity of fog-3 in vivo. These results...