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LiverZap activation elicits hepatocyte death and can be modulated.  (A) The...
Published: 21 February 2024
Fig. 1. LiverZap activation elicits hepatocyte death and can be modulated. (A) The LiverZap system expresses the photosensitising protein dL5** in hepatocytes. Upon combination with the dye MG-2I and NIR activation, ROS production triggers cell death. (B-E) Following NIR illumination, Acridine O... More about this image found in LiverZap activation elicits hepatocyte death and can be modulated. (A) The...
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Severe liver injury after LiverZap activation triggers the LPC programme.  ...
Published: 21 February 2024
Fig. 2. Severe liver injury after LiverZap activation triggers the LPC programme. (A-C‴) Expression of tg(Tp1:H2B-mCherry) marking BECs (grey) and tg(fabp10a:eGFP) highlighting hepatocytes (green) is mutually exclusive in control and mildly ablated livers (A-B″; N =4, n >7). In severely... More about this image found in Severe liver injury after LiverZap activation triggers the LPC programme. ...
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LiverZap ROI activation triggers a local LPC response.  (A) Local activatio...
Published: 21 February 2024
Fig. 3. LiverZap ROI activation triggers a local LPC response. (A) Local activation of LiverZap using a confocal microscope WLL tuned at 660 nm. (B,C) Acridine Orange (magenta) marks apoptotic cells after ROI LiverZap activation; hepatocytes express tg(fabbp10a:eGFP) (green; N =3, n =3). Max... More about this image found in LiverZap ROI activation triggers a local LPC response. (A) Local activatio...
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Dynamic cell rearrangement is a central part of injury-induced biliary netw...
Published: 21 February 2024
Fig. 4. Dynamic cell rearrangement is a central part of injury-induced biliary network aggregation. (A-H) tg(tp1:H2B-mCherry) -positive nuclei (magenta) serve as a proxy for biliary network remodelling during ablation and regeneration ( N =2, n >3); 10 µm masked maximum intensity projection... More about this image found in Dynamic cell rearrangement is a central part of injury-induced biliary netw...
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Functional differences between EOM and TA MuSCs after activation.  (A) Expe...
Published: 21 February 2024
Fig. 1. Functional differences between EOM and TA MuSCs after activation. (A) Experimental scheme. Adult MuSCs isolated from Tg:Pax7-nGFP mice were plated in growth media (GM) and pulsed with EdU before fixation and immunostaining at day (D) 3, D4, D5 and D10. Media was changed every second da... More about this image found in Functional differences between EOM and TA MuSCs after activation. (A) Expe...
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Single cell transcriptome signatures of activated EOM and TA MuSCs.  (A) sc...
Published: 21 February 2024
Fig. 2. Single cell transcriptome signatures of activated EOM and TA MuSCs. (A) scRNA-seq pipeline for in vitro -activated adult MuSCs. (B) UMAP visualisation of EOM progenitors, EOM differentiating, TA progenitors and TA differentiating clusters (left). Violin plots of the expression of myogen... More about this image found in Single cell transcriptome signatures of activated EOM and TA MuSCs. (A) sc...
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Molecular signature of EOM and TA quiescent MuSCs.  (A) scRNA-seq pipeline ...
Published: 21 February 2024
Fig. 3. Molecular signature of EOM and TA quiescent MuSCs. (A) scRNA-seq pipeline for quiescent adult MuSCs. (B) UMAP visualisation of EOM and TA quiescent clusters. (C,D) Violin plot (C) and expression plot (D) of Myf5 , Pax7 , Myod and Myog . (E) Heatmap representing the top differentiall... More about this image found in Molecular signature of EOM and TA quiescent MuSCs. (A) scRNA-seq pipeline ...
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EOM MuSC activation is accompanied by ECM remodelling.  (A) Violin plots of...
Published: 21 February 2024
Fig. 4. EOM MuSC activation is accompanied by ECM remodelling. (A) Violin plots of matrisome scores for each cluster of the in vitro -activated scRNA-seq MuSC dataset. (B) Dot plot visualisation of differentially expressed matrisome components. ECM, extracellular matrix; A-P, affiliated protein... More about this image found in EOM MuSC activation is accompanied by ECM remodelling. (A) Violin plots of...
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Distinct gene regulatory networks underlie EOM and TA activation dynamics. ...
Published: 21 February 2024
Fig. 5. Distinct gene regulatory networks underlie EOM and TA activation dynamics. (A) Representative top regulon activity for each cluster of the in vitro -activated adult scRNA-seq MuSC dataset overlaid onto UMAP representation. (B) Heatmap of the top five regulons in each cluster with activi... More about this image found in Distinct gene regulatory networks underlie EOM and TA activation dynamics. ...
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EOM MuSC properties are retained despite several passages  in vitro .  (A) ...
Published: 21 February 2024
Fig. 6. EOM MuSC properties are retained despite several passages in vitro . (A) Scheme of isolation and passages of EOM and TA adult MuSCs. Cells from Tg:Pax7-nGFP;Myog ntdTom were cultured for 3 days (Act) and the entire wells passaged (P1 and P2) every 3 days. (B) Normalised cell number r... More about this image found in EOM MuSC properties are retained despite several passages in vitro . (A) ...
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EOM activated MuSC features are present during postnatal growth and can be ...
Published: 21 February 2024
Fig. 7. EOM activated MuSC features are present during postnatal growth and can be modulated by FOXC1. (A) Scheme of isolation of EOM and TA GFP + /TOM − cells from Tg:Pax7-nGFP;Myog ntdTom from postnatal day (P)7-P10 mice. (B) RT-qPCR for key myogenic markers, regulon TFs and matrisome gene... More about this image found in EOM activated MuSC features are present during postnatal growth and can be ...
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RNA velocity reveals distinct population kinetics and potential key regulat...
Published: 21 February 2024
Fig. 8. RNA velocity reveals distinct population kinetics and potential key regulators of progenitor maintenance. (A) Number of regulatory links between regulons and matrisome genes depending on the number of top regulons in EOM and TA in vitro -activated scRNA-seq MuSC datasets. (B) Ratio of t... More about this image found in RNA velocity reveals distinct population kinetics and potential key regulat...
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